Gene
dvl3a
- ID
- ZDB-GENE-010319-1
- Name
- dishevelled segment polarity protein 3a
- Symbol
- dvl3a Nomenclature History
- Previous Names
-
- dvl3
- wu:fb75f04
- wu:fi22h02
- wu:fp61b09
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable frizzled binding activity. Involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway. Acts upstream of or within canonical Wnt signaling pathway; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Located in cell cortex and spindle. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55261 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Xing et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14810 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19682 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31259 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32847 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sdu16 | Allele with one deletion | Unknown | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dvl3a | (2) | |
| CRISPR2-dvl3a | (2) | |
| CRISPR3-dvl3a | (2) | |
| CRISPR4-dvl3a | (2) | |
| MO1-dvl3a | N/A | (6) |
| TALEN1-dvl3a | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant Robinow syndrome 3 | Alliance | Robinow syndrome, autosomal dominant 3 | 616894 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DEP domain | Dishevelled C-terminal | Dishevelled family | Dishevelled protein domain | Dishevelled-related protein | DIX domain | DIX domain superfamily | PDZ domain | PDZ superfamily | Ubiquitin-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8JMI2 | InterPro | 676 |
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Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-20K7 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-170O4 | ZFIN Curated Data | |
| Encodes | EST | fb75f04 | ||
| Encodes | EST | fi22h02 | ||
| Encodes | EST | fp61b09 | ||
| Encodes | cDNA | MGC:55261 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114008 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192732 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131757 (1) | 3009 nt | ||
| Genomic | GenBank:CU633992 (2) | 39137 nt | ||
| Polypeptide | UniProtKB:B8JMI2 (1) | 676 aa |
- Zhang, C., Wei, W., Lu, T., Zhang, Y., Li, J., Wang, J., Chen, A., Wen, F., Shao, M. (2024) Generation of Zebrafish Maternal Mutants via Oocyte-Specific Knockout System. Bio-protocol. 14:e5092e5092
- Shull, L.C., Lencer, E.S., Kim, H.M., Goyama, S., Kurokawa, M., Costello, J.C., Jones, K., Artinger, K.B. (2022) PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. Development (Cambridge, England). 149(4):
- Atienzar-Aroca, R., Aroca-Aguilar, J.D., Alexandre-Moreno, S., Ferre-Fernández, J.J., Bonet-Fernández, J.M., Cabañero-Varela, M.J., Escribano, J. (2021) Knockout of myoc Provides Evidence for the Role of Myocilin in Zebrafish Sex Determination Associated with Wnt Signalling Downregulation. Biology. 10(2):
- Gong, Y., Wu, F., Li, H., Zhang, X., Zhang, S. (2021) Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein. Developmental and comparative immunology. 121:104099
- Zhang, C., Li, J., Tarique, I., Zhang, Y., Lu, T., Wang, J., Chen, A., Wen, F., Zhang, Z., Zhang, Y., Shao, M. (2021) A Time-Saving Strategy to Generate Double Maternal Mutants by an Oocyte-Specific Conditional Knockout System in Zebrafish. Biology. 10(8)
- Menon, T., Borbora, A.S., Kumar, R., Nair, S. (2020) Dynamic optima in cell sizes during early development enable normal gastrulation in zebrafish embryos. Developmental Biology. 468(1-2):26-40
- Sun, H., Wang, Y., Zhang, J., Chen, Y., Liu, Y., Lin, Z., Liu, M., Sheng, K., Liao, H., Tsang, K.S., Zhang, X., Jiang, X., Xu, W., Mao, M., Chan, H.C. (2018) CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis. Cell Death & Disease. 9:275
- Xing, Y.Y., Cheng, X.N., Li, Y.L., Zhang, C., Saquet, A., Liu, Y.Y., Shao, M., Shi, D.L. (2018) Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements. PLoS Genetics. 14:e1007551
- Cheng, X.N., Shao, M., Li, J.T., Wang, Y.F., Qi, J., Xu, Z.G., Shi, D.L. (2017) Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. Nature communications. 8:1353
- Lai, K.P., Li, J.W., Hsu, C.H., You, M.S., Chan, T.F., Tse, W.K.F., Jiang, Y.J. (2017) Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish.. Gene. 642:51-57
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