Gene
slit2
- ID
- ZDB-GENE-010306-3
- Name
- slit homolog 2 (Drosophila)
- Symbol
- slit2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable Roundabout binding activity and heparin binding activity. Acts upstream of or within several processes, including endocardial progenitor cell migration to the midline involved in heart field formation; negative regulation of axon extension; and nervous system development. Predicted to be located in extracellular space. Is expressed in several structures, including axial mesoderm; forebrain neural tube; hypochord; nervous system; and oocyte. Orthologous to human SLIT2 (slit guidance ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ipm1 | Allele with one deletion | Exon 1 | Frameshift | CRISPR | |
la028107Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa231 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa1772 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12974 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa15818 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa39610 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zko456a | Allele with one deletion | Unknown | Unknown | CRISPR | |
zko456b | Allele with one deletion | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-slit2 | (2) | |
CRISPR2-slit2 | (2) | |
CRISPR3-slit2 | (2) | |
CRISPR4-slit2 | Davison et al., 2021 | |
CRISPR5-slit2 | Davison et al., 2021 | |
MO1-slit2 | N/A | (5) |
MO2-slit2 | N/A | Fish et al., 2011 |
MO3-slit2 | N/A | Hofmeister et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR013032 | EGF-like, conserved site |
Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
Domain | IPR000742 | EGF-like domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | Cysteine-rich flanking region, C-terminal | Cystine knot, C-terminal | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Follistatin-like, N-terminal | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Notch and Slit guidance protein |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PWQ2 | InterPro | 1527 | ||||||||||||||||
UniProtKB:A0A8M9QD73 | InterPro | 1520 | ||||||||||||||||
UniProtKB:A0A8M9Q7S3 | InterPro | 1544 | ||||||||||||||||
UniProtKB:A0A8M9Q2G6 | InterPro | 1540 | ||||||||||||||||
UniProtKB:A0A8M9Q7S7 | InterPro | 1533 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:slit2-GFP) |
|
| 5 | (15) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-250N21 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-144H23 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-162A7 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131735 (1) | 4539 nt | ||
Genomic | GenBank:CR376790 (1) | 129495 nt | ||
Polypeptide | UniProtKB:A0A8M9Q2G1 (1) | 1551 aa |
- Zhou, L., Zhang, W., Xiang, Y., Qian, Z., Zhou, J., Ni, L., Feng, Y., Gao, B. (2023) The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC. Open life sciences. 18:2022053320220533
- Davison, C., Bedó, G., Zolessi, F.R. (2022) Zebrafish Slit2 and Slit3 Act Together to Regulate Retinal Axon Crossing at the Midline. Journal of developmental biology. 10(4):
- Davison, C., Zolessi, F.R. (2021) Slit2 is necessary for optic axon organization in the zebrafish ventral midline. Cells & development. 166:203677
- Knickmeyer, M.D., Mateo, J.L., Heermann, S. (2021) BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Chen, K., Fan, Y., Gu, J., Han, Z., Zeng, H., Mao, C., Wang, C. (2020) In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4'-Dimethyl Ether. Drug design, development and therapy. 14:3069-3078
- Terzi, A., Roeder, H., Weaver, C.J., Suter, D.M. (2020) Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2. Developmental Neurobiology. 81(1):3-21
- Zhang, Q., Zhang, C., Zhang, C., Peng, G. (2020) Wnt Signaling Regulates Ipsilateral Pathfinding in the Zebrafish Forebrain through slit3. Neuroscience. 449:9-20
- Lu, T., Zhang, T., Wang, C., Yang, N., Pan, Y.H., Dang, S., Zhang, W. (2019) Adamts18 deficiency in zebrafish embryo causes defective trunk angiogenesis and caudal vein plexus formation. Biochemical and Biophysical Research Communications. 521(4):907-913
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Turner, K.J., Hoyle, J., Valdivia, L.E., Cerveny, K.L., Hart, W., Mangoli, M., Geisler, R., Rees, M., Houart, C., Poole, R.J., Wilson, S.W., Gestri, G. (2019) Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 14:e0211073
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