Gene

slit2

ID
ZDB-GENE-010306-3
Name
slit homolog 2 (Drosophila)
Symbol
slit2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable Roundabout binding activity and heparin binding activity. Acts upstream of or within several processes, including endocardial progenitor cell migration to the midline involved in heart field formation; negative regulation of axon extension; and nervous system development. Predicted to be located in extracellular space. Is expressed in several structures, including axial mesoderm; forebrain neural tube; hypochord; nervous system; and oocyte. Orthologous to human SLIT2 (slit guidance ligand 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ipm1Allele with one deletionExon 1FrameshiftCRISPR
la028107TgTransgenic insertionUnknownUnknownDNA
sa231Allele with one point mutationUnknownPremature StopENU
sa1772Allele with one point mutationUnknownPremature StopENU
sa12974Allele with one point mutationUnknownPremature StopENU
sa15818Allele with one point mutationUnknownPremature StopENU
sa39610Allele with one point mutationUnknownPremature StopENU
zko456aAllele with one deletionUnknownUnknownCRISPR
zko456bAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With slit2 Human Ortholog
No data available
Associated With slit2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000372 Leucine-rich repeat N-terminal domain
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Domain IPR000742 EGF-like domain
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Domain Details Per Protein
Protein Additional Resources Length Concanavalin A-like lectin/glucanase domain superfamily Cysteine-rich flanking region, C-terminal Cystine knot, C-terminal EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Follistatin-like, N-terminal Growth factor receptor cysteine-rich domain superfamily Laminin G domain Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat N-terminal domain Leucine-rich repeat, typical subtype Notch and Slit guidance protein
UniProtKB:A0A8M9PWQ2 InterPro 1527
UniProtKB:A0A8M9QD73 InterPro 1520
UniProtKB:A0A8M9Q7S3 InterPro 1544
UniProtKB:A0A8M9Q2G6 InterPro 1540
UniProtKB:A0A8M9Q7S7 InterPro 1533
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA slit2-201 (1) Ensembl 7,426 nt
mRNA slit2-202 (1) Ensembl 8,663 nt
mRNA slit2-203 (1) Ensembl 8,553 nt
mRNA slit2-204 (1) Ensembl 8,690 nt
mRNA slit2-205 (1) Ensembl 8,649 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(hsp70l:slit2-GFP)
  • Danio rerio
5 (15)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-250N21ZFIN Curated Data
Contained inFosmidCH1073-144H23ZFIN Curated Data
Contained inFosmidCH1073-162A7ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSLIT24
Amino acid sequence comparison (2)
MouseSlit25
Amino acid sequence comparison (1)
Citations
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