Gene

gdnfa

ID
ZDB-GENE-010226-1
Name
glial cell derived neurotrophic factor a
Symbol
gdnfa Nomenclature History
Previous Names
  • gdnf
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Enables MAP kinase kinase kinase activity. Acts upstream of or within nervous system development; protein-containing complex assembly; and regulation of dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; eye; gut; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; alcohol dependence; alcohol use disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb822Allele with one deletionExon 3UnknownCRISPR
ot218Allele with one deletionExon 3UnknownCRISPR
ihb823Allele with one deletionExon 3UnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With gdnfa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Hirschsprung disease, susceptibility to, 3} 613711
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Associated With gdnfa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001839 Transforming growth factor-beta, C-terminal
Domain IPR047020 Glial cell line-derived neurotrophic factor, TGF-beta-like domain
Family IPR016649 Glial cell line-derived neurotrophic factor
Family IPR043401 Glial cell line-derived neurotrophic factor family
Homologous_superfamily IPR029034 Cystine-knot cytokine
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Domain Details Per Protein
Protein Additional Resources Length Cystine-knot cytokine Glial cell line-derived neurotrophic factor Glial cell line-derived neurotrophic factor family Glial cell line-derived neurotrophic factor, TGF-beta-like domain Transforming growth factor-beta, C-terminal
UniProtKB:Q98TU0 InterPro PDB 235
UniProtKB:A7E220 InterPro 235
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 10
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gdnfa-201 (1) Ensembl 2,258 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(gdnfa:mCherry)
  • gdnfa
  • Danio rerio
1Liao et al., 2023
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-391M17ZFIN Curated Data
Contained inFosmidZFOS-410G7ZFIN Curated Data
EncodescDNAMGC:158214ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGDNF5
Amino acid sequence comparison (5)
Conserved genome location (synteny) (1)
MouseGdnf15
Amino acid sequence comparison (3)
Citations
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