Gene
gdnfa
- ID
- ZDB-GENE-010226-1
- Name
- glial cell derived neurotrophic factor a
- Symbol
- gdnfa Nomenclature History
- Previous Names
-
- gdnf
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables MAP kinase kinase kinase activity. Acts upstream of or within nervous system development; protein-containing complex assembly; and regulation of dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; eye; gut; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; alcohol dependence; alcohol use disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Hirschsprung disease, susceptibility to, 3} | 613711 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Domain | IPR047020 | Glial cell line-derived neurotrophic factor, TGF-beta-like domain |
| Family | IPR016649 | Glial cell line-derived neurotrophic factor |
| Family | IPR043401 | Glial cell line-derived neurotrophic factor family |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Glial cell line-derived neurotrophic factor | Glial cell line-derived neurotrophic factor family | Glial cell line-derived neurotrophic factor, TGF-beta-like domain | Transforming growth factor-beta, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q98TU0 | InterPro PDB | 235 | |||||
| UniProtKB:A7E220 | InterPro | 235 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gdnfa:mCherry) |
|
| 1 | Liao et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-391M17 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-410G7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158214 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131732 (1) | 1849 nt | ||
| Genomic | GenBank:CU928210 (2) | 35807 nt | ||
| Polypeptide | UniProtKB:A7E220 (1) | 235 aa |
- Kalyn, M., Garvey, R., Lee, H., Mbesha, H.A., Curry, J., Saxena, V., Mennigen, J.A., Ekker, M. (2024) Differential roles of NR4A2 (NURR1) paralogs in the brain and behavior of zebrafish. Journal of neurochemistry. :
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Adams, S.E., Purkiss, A.G., Knowles, P.P., Nans, A., Briggs, D.C., Borg, A., Earl, C.P., Goodman, K.M., Nawrotek, A., Borg, A.J., McIntosh, P.B., Houghton, F.M., Kjær, S., McDonald, N.Q. (2021) A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing. Structure (London, England : 1993). 29(7):694-708.e7
- Barui, A.K., Jhelum, P., Nethi, S.K., Das, T., Bhattacharya, D., B, V., Karri, S., Chakravarty, S., Patra, C.R. (2020) Potential Therapeutic Application of Zinc Oxide Nanoflowers in the Cerebral Ischemia Rat Model through Neuritogenic and Neuroprotective Properties. Bioconjugate Chemistry. 31:895-906
- Das, T., Soren, K., Yerasi, M., Kamle, A., Kumar, A., Chakravarty, S. (2020) Molecular Basis of Sex Difference in Neuroprotection induced by Hypoxia Preconditioning in Zebrafish. Molecular neurobiology. 57(12):5177-5192
- Wong, C.E.D., Hua, K., Monis, S., Norazit, A., Noor, S.M., Ekker, M. (2020) Cellular Localization of gdnf in Adult Zebrafish Brain. Brain sciences. 10(5):
- Wong, C.E.D., Hua, K., Monis, S., Saxena, V., Norazit, A., Noor, S.M., Ekker, M. (2020) Gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish. Journal of neurochemistry. 156(4):481-498
- Zhu, X.Y., Xia, B., Ye, T., Dai, M.Z., Yang, H., Li, C.Q., Li, P. (2020) Ponatinib-induced ischemic stroke in larval zebrafish for drug screening. European Journal of Pharmacology. 889:173292
- Huang, S., Wang, Y., Luo, L., Li, X., Jin, X., Li, S., Yu, X., Yang, M., Guo, Z. (2019) BMP2 Is Related to Hirschsprung's Disease and Required for Enteric Nervous System Development. Frontiers in Cellular Neuroscience. 13:523
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