Gene
gcga
- ID
- ZDB-GENE-010219-1
- Name
- glucagon a
- Symbol
- gcga Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables glucagon receptor binding activity. Acts upstream of or within response to starvation and type B pancreatic cell development. Predicted to be located in extracellular region. Is expressed in endocrine system; endoderm; gut; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease and prediabetes syndrome. Orthologous to human GCG (glucagon).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 96 figures from 53 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103616 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa43786 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glucagon | Glucagon/GIP/secretin/VIP |
|---|---|---|---|---|
| UniProtKB:F1RD10 | InterPro | 121 | ||
| UniProtKB:A0A0R4IS85 | InterPro | 176 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gcga:caHsa.MTOR_L1460P,cryaa:TagRFP) |
|
| 1 | Gong et al., 2023 | |
| Tg(gcga:caRno.Rheb_S16H,cryaa:YFP) |
|
| 1 | Gong et al., 2023 | |
| Tg(gcga:Cre,cryaa:Venus) |
|
| 1 | (5) | |
| Tg(gcga:dnHsa.ERBB1,cryaa:Cerulean) |
|
| 1 | Kang et al., 2024 | |
| Tg(gcga:GFP) |
|
| 1 | (48) | |
| Tg(gcga:H2B-mCherry) |
|
| 1 | Kang et al., 2022 | |
| Tg(gcga:hM3Dq,cryaa:TagRFP) |
|
| 1 | Gong et al., 2023 | |
| Tg(gcga:hM4Di,cryaa:TagRFP) |
|
| 1 | Gong et al., 2023 | |
| Tg(gcga:Hsa.CASR,cryaa:TagRFP) |
|
| 1 | Gong et al., 2023 |
1 - 9 of 9
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-2D23 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-467M9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103616 | Strausberg et al., 2002 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001008595 (1) | 1770 nt | ||
| Genomic | GenBank:CU570889 (2) | 52554 nt | ||
| Polypeptide | UniProtKB:A0A0R4IS85 (1) | 176 aa |
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Chen, Z., He, M., Wang, H., Li, X., Qin, R., Ye, D., Zhai, X., Zhu, J., Zhang, Q., Hu, P., Shui, G., Sun, Y. (2024) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Nature communications. 15:97699769
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007
- Kang, Q., Jia, J., Dean, E.D., Yuan, H., Dai, C., Li, Z., Jiang, F., Zhang, X.K., Powers, A.C., Chen, W., Li, M. (2024) ErbB3 is required for hyperaminoacidemia-induced pancreatic α cell hyperplasia. The Journal of biological chemistry. 300(8):107499
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Gong, Y., Yang, B., Zhang, D., Zhang, Y., Tang, Z., Yang, L., Coate, K.C., Yin, L., Covington, B.A., Patel, R.S., Siv, W.A., Sellick, K., Shou, M., Chang, W., Danielle Dean, E., Powers, A.C., Chen, W. (2023) Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways. Nature communications. 14:235235
- Fang, Y., Wan, J.P., Zhang, R.J., Sun, F., Yang, L., Zhao, S.X., Dong, M., Song, H.D. (2022) Tpo knockout in zebrafish partially recapitulates clinical manifestations of congenital hypothyroidism and reveals the involvement of TH in proper development of glucose homeostasis. General and comparative endocrinology. 323-324:114033
- Kang, Q., Zheng, J., Jia, J., Xu, Y., Bai, X., Chen, X., Zhang, X.K., Wong, F.S., Zhang, C., Li, M. (2022) Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish. The Journal of biological chemistry. 298(12):102665
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
1 - 10 of 102
Show