Gene
mdkb
- ID
- ZDB-GENE-010131-6
- Name
- midkine b
- Symbol
- mdkb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity. Acts upstream of or within brain development; neural crest formation; and positive regulation of neuron differentiation. Located in extracellular region. Is expressed in several structures, including brain; neural keel; neural rod; neural tube; and retina. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb518 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Liedtke et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mi5002 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ns18 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa24609 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32516 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38006 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020089 | Pleiotrophin/Midkine, N-terminal domain |
| Domain | IPR020090 | Pleiotrophin/Midkine, C-terminal domain |
| Family | IPR000762 | Midkine heparin-binding growth factor |
| Homologous_superfamily | IPR020091 | Pleiotrophin/Midkine disulphide-rich domain superfamily |
| Homologous_superfamily | IPR037122 | Pleiotrophin/Midkine, N-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Midkine heparin-binding growth factor | Pleiotrophin/Midkine, C-terminal domain | Pleiotrophin/Midkine, C-terminal domain superfamily | Pleiotrophin/Midkine disulphide-rich domain superfamily | Pleiotrophin/Midkine, N-terminal domain | Pleiotrophin/Midkine, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DDG2 | InterPro PDB | 147 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-151M17 | ZFIN Curated Data | |
| Contains | SNP | rs3729357 | ZFIN Curated Data | |
| Contains | SNP | rs3729358 | ZFIN Curated Data | |
| Contains | SNP | rs3729359 | ZFIN Curated Data | |
| Encodes | EST | cb518 | Thisse et al., 2001 | |
| Encodes | EST | fb79b05 | ZFIN Curated Data | |
| Encodes | EST | fj33b02 | ZFIN Curated Data | |
| Encodes | EST | fj48a12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73234 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131716 (1) | 1018 nt | ||
| Genomic | GenBank:CU181898 (2) | 122601 nt | ||
| Polypeptide | UniProtKB:Q9DDG2 (1) | 147 aa |
- Le, Y., Rajasekhar, K., Loo, T.Y.J., Saunders, T.E., Wohland, T., Winkler, C. (2025) Midkine-a interacts with Ptprz1b to regulate neural plate convergence and midline formation in the developing zebrafish hindbrain. Developmental Biology. :
- Kapuria, S., Bai, H., Fierros, J., Huang, Y., Ma, F., Yoshida, T., Aguayo, A., Kok, F., Wiens, K.M., Yip, J.K., McCain, M.L., Pellegrini, M., Nagashima, M., Hitchcock, P.F., Mochizuki, N., Lawson, N.D., Harrison, M.M.R., Lien, C.L. (2022) Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration. Development (Cambridge, England). 149(4):
- Lübke, L., Zhang, G., Strähle, U., Rastegar, S. (2022) mdka Expression Is Associated with Quiescent Neural Stem Cells during Constitutive and Reactive Neurogenesis in the Adult Zebrafish Telencephalon. Brain sciences. 12(2):
- Grivas, D., González-Rajal, Á., de la Pompa, J.L. (2021) Midkine-a Regulates the Formation of a Fibrotic Scar During Zebrafish Heart Regeneration. Frontiers in cell and developmental biology. 9:669439
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Zhang, Z., Qin, Z. (2018) Characterization of Midkine in tongue sole (Cynoglossus semilaevis)and its role on the germ layer genesis in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 226:64-72
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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