Gene

mdkb

ID
ZDB-GENE-010131-6
Name
midkine b
Symbol
mdkb Nomenclature History
Previous Names
  • mdk2 (1)
  • mdk
  • cb518 (1)
  • fb79b05
  • fj33b02
  • fj48a12
  • plei2
  • pleiotrophin 2
  • wu:fb79b05 (1)
  • wu:fj33b02 (1)
  • wu:fj48a12 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable growth factor activity. Acts upstream of or within brain development; neural crest formation; and positive regulation of neuron differentiation. Located in extracellular region. Is expressed in several structures, including brain; neural keel; neural rod; neural tube; and retina. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
31 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Liedtke et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
mi5002Allele with one deletionUnknownUnknownCRISPR
ns18Allele with one deletionUnknownUnknownCRISPR
sa24609Allele with one point mutationUnknownSplice SiteENU
sa32516Allele with one point mutationUnknownSplice SiteENU
sa38006Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Human Disease
Associated With mdkb Human Ortholog
No data available
Associated With mdkb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020089 Pleiotrophin/Midkine, N-terminal domain
Domain IPR020090 Pleiotrophin/Midkine, C-terminal domain
Family IPR000762 Midkine heparin-binding growth factor
Homologous_superfamily IPR020091 Pleiotrophin/Midkine disulphide-rich domain superfamily
Homologous_superfamily IPR037122 Pleiotrophin/Midkine, N-terminal domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Midkine heparin-binding growth factor Pleiotrophin/Midkine, C-terminal domain Pleiotrophin/Midkine, C-terminal domain superfamily Pleiotrophin/Midkine disulphide-rich domain superfamily Pleiotrophin/Midkine, N-terminal domain Pleiotrophin/Midkine, N-terminal domain superfamily
UniProtKB:Q9DDG2 InterPro PDB 147
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mdkb-201 (1) Ensembl 1,100 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanMDK11
Phylogenetic tree (1)
Amino acid sequence comparison (4)
Conserved genome location (synteny) (1)
MouseMdk2
Amino acid sequence comparison (3)
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
Citations
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