Gene

atp1a2a

ID
ZDB-GENE-001212-6
Name
ATPase Na+/K+ transporting subunit alpha 2a
Symbol
atp1a2a Nomenclature History
Previous Names
  • atp[a]2 (1)
  • cb702 (1)
  • fa10d04
  • fa10d05
  • wu:fa10d05 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within several processes, including heart looping; specification of animal organ axis polarity; and thigmotaxis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; brain; musculature system; pharyngeal arch 3-7 skeleton; and pronephric duct. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; electroclinical syndrome (multiple); hypertension; and migraine with aura (multiple). Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la023718TgTransgenic insertionUnknownUnknownDNA
sa9321Allele with one point mutationUnknownSplice SiteENU
sa11860Allele with one point mutationUnknownPremature StopENU
sa18737Allele with one point mutationUnknownPremature StopENU
sa33010Allele with one point mutationUnknownSplice SiteENU
sa33011Allele with one point mutationUnknownPremature StopENU
sa39924Allele with one point mutationUnknownPremature StopENU
sa39925Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-atp1a2aN/A (3)
MO2-atp1a2aN/AShu et al., 2007
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Human Disease
Associated With atp1a2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alternating hemiplegia of childhood Alliance Alternating hemiplegia of childhood 1 104290
developmental and epileptic encephalopathy 98 Alliance Developmental and epileptic encephalopathy 98 619605
familial hemiplegic migraine 2 Alliance Migraine, familial basilar 602481
familial hemiplegic migraine 2 Alliance Migraine, familial hemiplegic, 2 602481
Fetal akinesia, respiratory insufficiency, microcephaly, polymicrogyria, and dysmorphic facies 619602
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Associated With atp1a2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004014 Cation-transporting P-type ATPase, N-terminal
Domain IPR006068 Cation-transporting P-type ATPase, C-terminal
Domain IPR044492 P-type ATPase, haloacid dehalogenase domain
Family IPR001757 P-type ATPase
Family IPR005775 P-type ATPase subfamily IIC, subunit alpha
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Domain Details Per Protein
Protein Additional Resources Length Cation transport ATPase (P-type) Cation-transporting P-type ATPase, C-terminal Cation-transporting P-type ATPase, N-terminal HAD-like superfamily HAD superfamily P-type ATPase P-type ATPase, A domain superfamily P-type ATPase, cytoplasmic domain N P-type ATPase, haloacid dehalogenase domain P-type ATPase, phosphorylation site P-type ATPase subfamily IIC, subunit alpha P-type ATPase, transmembrane domain superfamily
UniProtKB:Q9DGL5 InterPro 1017
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA atp1a2a-201 (1) Ensembl 3,907 nt
mRNA atp1a2a-202 (1) Ensembl 3,869 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEYP-35B8ZFIN Curated Data
EncodesESTcb702
    (2)
    EncodesESTfa10d04Rajarao et al., 2001
    EncodesESTfa10d05ZFIN Curated Data
    EncodescDNAMGC:194325ZFIN Curated Data
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanATP1A21
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (2)
    MouseAtp1a21
    Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Citations
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