Gene
atp1a2a
- ID
- ZDB-GENE-001212-6
- Name
- ATPase Na+/K+ transporting subunit alpha 2a
- Symbol
- atp1a2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within several processes, including heart looping; specification of animal organ axis polarity; and thigmotaxis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; brain; musculature system; pharyngeal arch 3-7 skeleton; and pronephric duct. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; electroclinical syndrome (multiple); hypertension; and migraine with aura (multiple). Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb702 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023718Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9321 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11860 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18737 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33010 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33011 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39924 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39925 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-atp1a2a | N/A | (3) |
| MO2-atp1a2a | N/A | Shu et al., 2007 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alternating hemiplegia of childhood | Alliance | Alternating hemiplegia of childhood 1 | 104290 |
| developmental and epileptic encephalopathy 98 | Alliance | Developmental and epileptic encephalopathy 98 | 619605 |
| familial hemiplegic migraine 2 | Alliance | Migraine, familial basilar | 602481 |
| familial hemiplegic migraine 2 | Alliance | Migraine, familial hemiplegic, 2 | 602481 |
| Fetal akinesia, respiratory insufficiency, microcephaly, polymicrogyria, and dysmorphic facies | 619602 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Family | IPR001757 | P-type ATPase |
| Family | IPR005775 | P-type ATPase subfamily IIC, subunit alpha |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cation transport ATPase (P-type) | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase subfamily IIC, subunit alpha | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DGL5 | InterPro | 1017 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp1a2a-201
(1)
|
Ensembl | 3,907 nt | ||
| mRNA |
atp1a2a-202
(1)
|
Ensembl | 3,869 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-35B8 | ZFIN Curated Data | |
| Encodes | EST | cb702 | (2) | |
| Encodes | EST | fa10d04 | Rajarao et al., 2001 | |
| Encodes | EST | fa10d05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194325 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131683 (1) | 3889 nt | ||
| Genomic | GenBank:AL935192 (1) | 192649 nt | ||
| Polypeptide | UniProtKB:Q9DGL5 (1) | 1017 aa |
- Maters, B.R., Stevenson, E., Vize, P.D. (2022) Embryonic and aglomerular kidney development in the bay pipefish, Syngnathus leptorhynchus. PLoS One. 17:e0267932
- Esbaugh, A.J., Brix, K.V., Grosell, M. (2019) Na+ K+ ATPase isoform switching in zebrafish during transition to dilute freshwater habitats. Proceedings. Biological sciences. 286:20190630
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- D'Aurizio, R., Russo, F., Chiavacci, E., Baumgart, M., Groth, M., D'Onofrio, M., Arisi, I., Rainaldi, G., Pitto, L., Pellegrini, M. (2016) Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Frontiers in bioengineering and biotechnology. 4:60
- Huang, L., Zuo, Z., Zhang, Y., Wang, C. (2015) Toxicogenomic analysis in the combined effect of tributyltin and benzo[a]pyrene on the development of zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 158C:157-164
- Priyadarshini, M., Tuimala, J., Chen, Y.C., and Panula, P. (2013) A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling. Neurobiology of disease. 54:127-38
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Doganli, C., Kjaer-Sorensen, K., Knoeckel, C., Beck, H.C., Nyengaard, J.R., Honoré, B., Nissen, P., Ribera, A., Oxvig, C., and Lykke-Hartmann, K. (2012) The alpha2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish. Journal of Cell Science. 125(24):6166-6175
- Liao, B.K., Chen, R.D., and Hwang, P.P. (2009) Expression regulation of Na+-K+-ATPase {alpha}1-subunit subtypes in zebrafish gill ionocytes. American journal of physiology. Regulatory, integrative and comparative physiology. 296(6):R1897-R1906
- Shu, X., Huang, J., Dong, Y., Choi, J., Langenbacher, A., and Chen, J.N. (2007) Na,K-ATPase α2 and Ncx4a regulate zebrafish left-right patterning. Development (Cambridge, England). 134(10):1921-1930
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