Gene
lbx2
- ID
- ZDB-GENE-001206-2
- Name
- ladybird homeobox 2
- Symbol
- lbx2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in several processes, including positive regulation of convergent extension involved in gastrulation; positive regulation of non-canonical Wnt signaling pathway; and posterior lateral line development. Acts upstream of or within muscle cell development and regulation of canonical Wnt signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; fin; mesoderm; musculature system; and presumptive paraxial mesoderm. Orthologous to human LBX2 (ladybird homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3336 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ihb39 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb40 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb241 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ko11 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | TALEN | |
| sa605 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3009 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zf3010 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lbx2 | (4) | |
| CRISPR2-lbx2 | Zebrafish Nomenclature Committee | |
| CRISPR3-lbx2 | Wang et al., 2018 | |
| MO1-lbx2 | N/A | Ochi et al., 2009 |
| MO2-lbx2 | N/A | Ochi et al., 2009 |
| MO3-lbx2 | N/A | (2) |
| MO4-lbx2 | N/A | Lou et al., 2012 |
| MO5-lbx2 | N/A | Lu et al., 2014 |
| MO6-lbx2 | N/A | Lu et al., 2014 |
| MO7-lbx2 | N/A | Lu et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LBX Family Transcription Factors |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q804R0 | InterPro | 257 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207O21 | ZFIN Curated Data | |
| Encodes | EST | bn0aa085zh02 | ZFIN Curated Data | |
| Encodes | EST | fc26c12 | ||
| Encodes | cDNA | MGC:92170 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007134 (1) | 1764 nt | ||
| Genomic | GenBank:AL831789 (1) | 217649 nt | ||
| Polypeptide | UniProtKB:Q804R0 (1) | 257 aa |
- Juárez-Morales, J.L., Weierud, F., England, S.J., Demby, C., Santos, N., Grieb, G., Mazan, S., Lewis, K.E. (2021) Evolution of lbx spinal cord expression and function. Evolution & development. 23(5):404-422
- Sagarin, K.A., Redgrave, A.C., Mosimann, C., Burke, A.C., Devoto, S.H. (2019) Anterior Trunk Muscle Shows Mix of Axial and Appendicular Developmental Patterns. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(10):961-968
- Talbot, J.C., Teets, E.M., Ratnayake, D., Duy, P.Q., Currie, P.D., Amacher, S.L. (2019) Muscle precursor cell movements in zebrafish are dynamic and require six-family genes. Development (Cambridge, England). 146(10):
- Wang, J., Luo, J., Chen, Q., Wang, X., He, J., Zhang, W., Yin, Z., Zheng, F., Pan, H., Li, T., Lou, Q., Wang, B. (2018) Identification of LBX2 as a novel causal gene of atrial septal defect. International Journal of Cardiology. 265:188-194
- Boswell, C.W., Ciruna, B. (2017) Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought. Trends in genetics : TIG. 33(3):183-196
- Masselink, W., Masaki, M., Sieiro, D., Marcelle, C., Currie, P.D. (2017) Phosphorylation of Lbx1 controls lateral myoblast migration into the limb. Developmental Biology. 430:302-309
- Guo, L., Yamashita, H., Kou, I., Takimoto, A., Meguro-Horike, M., Horike, S.I., Sakuma, T., Miura, S., Adachi, T., Yamamoto, T., Ikegawa, S., Hiraki, Y., Shukunami, C. (2016) Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation. PLoS Genetics. 12:e1005802
- Naylor, R.W., Skvarca, L.B., Thisse, C., Thisse, B., Hukriede, N.A., Davidson, A.J. (2016) BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nature communications. 7:12197
- Fang, X., Zhang, B., Thisse, B., Bloom, G.S., Thisse, C. (2015) IQGAP3 Is Essential for Cell Proliferation and Motility During Zebrafish Embryonic Development. Cytoskeleton (Hoboken, N.J.). 72(8):422-33
- Lours-Calet, C., Alvares, L.E., El-Hanfy, A.S., Gandesha, S., Walters, E.H., Sobreira, D.R., Wotton, K.R., Jorge, E.C., Lawson, J.A., Kelsey Lewis, A., Tada, M., Sharpe, C., Kardon, G., Dietrich, S. (2014) Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures. Developmental Biology. 390:231-46
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