Gene
aox5
- ID
- ZDB-GENE-001205-2
- Name
- aldehyde oxidase 5
- Symbol
- aox5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable aldehyde oxidase activity. Located in cytoplasm. Is expressed in several structures, including fin; neural crest; pigment cell; post-vent region; and xanthoblast. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1094 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa574 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18330 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37463 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37464 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37465 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39364 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43795 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR006058 | 2Fe-2S ferredoxin, iron-sulphur binding site |
| Domain | IPR000674 | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead |
| Domain | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| Domain | IPR002346 | Molybdopterin dehydrogenase, FAD-binding |
| Domain | IPR002888 | [2Fe-2S]-binding |
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Domain Details Per Protein
| Protein | Additional Resources | Length | [2Fe-2S]-binding | [2Fe-2S]-binding domain superfamily | 2Fe-2S ferredoxin, iron-sulphur binding site | 2Fe-2S ferredoxin-like superfamily | 2Fe-2S ferredoxin-type iron-sulfur binding domain | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily | Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain | Aldehyde oxidase/xanthine dehydrogenase-like | Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily | Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain | Beta-grasp domain superfamily | CO dehydrogenase flavoprotein, C-terminal | CO dehydrogenase flavoprotein, C-terminal domain superfamily | FAD-binding domain, PCMH-type | FAD-binding, type PCMH-like superfamily | FAD-binding, type PCMH, subdomain 1 | FAD-binding, type PCMH, subdomain 2 | Molybdopterin dehydrogenase, FAD-binding | Xanthine dehydrogenase, small subunit |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:M1ZMM0 | InterPro | 1336 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(aox5:ChR2_C128S_D156A-mCherry) |
|
| 1 | Aramaki et al., 2018 | |
| Tg(aox5:PALM-EGFP) |
|
| 1 | (8) | |
| Tg(aox5:PALM-GFP) |
|
| 1 | (6) | |
| Tg(aox5-RTTA-ubb:EGFP,TETRE:gja4-IRES-Hsa.HIST1H2BJ-RFP) |
| 1 | Usui et al., 2019 | ||
| Tg(aox5-RTTA-ubb:EGFP,TETRE:gja5b-IRES-Hsa.HIST1H2BJ-RFP) |
| 1 | Usui et al., 2019 | ||
| Tg(aox5:sat1b) |
|
| 1 | Usui et al., 2019 | |
| Tg(aox5:TETA-GBD,TETRE:NLS-Venus-2A-dnHsa.CDC42) |
|
| 1 | Eom et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-246M6 | ZFIN Curated Data | |
| Encodes | EST | eu1094 | Thisse et al., 2005 | |
| Encodes | EST | fc18g02 | (2) |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001278796 (1) | 4011 nt | ||
| Genomic | GenBank:BX649296 (1) | 175492 nt | ||
| Polypeptide | UniProtKB:M1ZMM0 (1) | 1336 aa |
No data available
- Korzeniwsky, K.G., de Mello, P.L.H., Liang, Y., Feltes, M., Farber, S.A., Parichy, D.M. (2025) Dominant Negative Mitf Allele Impacts Melanophore and Xanthophore Development and Reveals Collaborative Interactions With Tfec in Zebrafish Chromatophore Lineages. Pigment cell & melanoma research. 38:e70009e70009
- Karampelias, C., Băloiu, B., Rathkolb, B., da Silva-Buttkus, P., Bachar-Wikström, E., Marschall, S., Fuchs, H., Gailus-Durner, V., Chu, L., Hrabě de Angelis, M., Andersson, O. (2024) Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration. Life science alliance. 7(11):
- Frantz, W.T., Iyengar, S., Neiswender, J., Cousineau, A., Maehr, R., Ceol, C.J. (2023) Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish. eLIFE. 12:
- Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
- Xu, Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., Li, M. (2022) Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Frontiers in endocrinology. 13:864631
- Lencer, E., Prekeris, R., Artinger, K.B. (2021) Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. eLIFE. 10:
- Petratou, K., Spencer, S.A., Kelsh, R.N., Lister, J.A. (2021) The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor. PLoS One. 16:e0244794
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Gramann, A.K., Venkatesan, A.M., Guerin, M., Ceol, C.J. (2019) Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling. eLIFE. 8:
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