Gene
vtg2
- ID
- ZDB-GENE-001201-2
- Name
- vitellogenin 2
- Symbol
- vtg2 Nomenclature History
- Previous Names
-
- vg2
- si:dkey-4c23.2
- zfVtg2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables lipopolysaccharide binding activity and lipoteichoic acid binding activity. Acts upstream of or within positive regulation of phagocytosis, engulfment; response to estradiol; and vitelline membrane formation. Is expressed in atrium; digestive system; female organism; and male organism.
- Genome Resources
- Note
-
vtg2-201 and vtg2-202 are described in ZDB-PUB-180609-20. vtg2-201 corresponds to ENSDART00000078328 and vtg2-202 corresponds to ENSDART00000105263
- Comparative Information
-
- All Expression Data
- 23 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Yilmaz et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR3-vtg | (2) | |
| CRISPR4-vtg2 | Yilmaz et al., 2023 | |
| CRISPR5-vtg2 | Yilmaz et al., 2023 | |
| CRISPR6-vtg2 | Yilmaz et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Lipid transport protein, beta-sheet shell | Lipovitellin-phosvitin complex, superhelical domain | Vitellinogen, beta-sheet N-terminal | Vitellinogen, beta-sheet shell | Vitellinogen, beta-sheet shell domain superfamily | Vitellinogen, open beta-sheet | Vitellinogen, open beta-sheet, subdomain 1 | Vitellogenin/Apolipophorin | Vitellogenin, N-terminal | von Willebrand factor, type D domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1MTC4 | InterPro | 1631 | ||||||||||
| UniProtKB:A8WGJ1 | InterPro | 834 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-4C23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173488 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044913 (1) | 5002 nt | ||
| Genomic | GenBank:AL929032 (1) | 236775 nt | ||
| Polypeptide | UniProtKB:Q1MTC4 (1) | 1631 aa |
No data available
- Liu, Z., Zhang, N., Wang, C., Shi, L., Hu, Y., Wang, Y., Li, J. (2024) Lrp13a and Lrp13b serve as vitellogenin receptors in the ovary of zebrafish†. Biology of reproduction. 111(1):123-134
- Uju, C., Karimzadeh, K., Unniappan, S. (2024) Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 169(1):
- Zhu, B., Zhang, Z., Pardeshi, L., Chen, Y., Ge, W. (2024) Role of Y box-binding protein 1 (Ybx1) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of p21 (cdkn1a). Development (Cambridge, England). 151(21):
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Yilmaz, O., Com, E., Pineau, C., Bobe, J. (2023) Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio). Scientific Reports. 13:1879518795
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Chen, X., Zheng, J., Zhang, J., Duan, M., Xu, H., Zhao, W., Yang, Y., Wang, C., Xu, Y. (2022) Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior. The Science of the total environment. 838(Pt 1):155610
- Duan, M., Guo, X., Chen, X., Guo, M., Xu, H., Hao, L., Wang, C., Yang, Y. (2022) Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish. Toxics. 10(9)
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
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