Gene
efna5a
- ID
- ZDB-GENE-001128-1
- Name
- ephrin-A5a
- Symbol
- efna5a Nomenclature History
- Previous Names
-
- cb1080 (1)
- fl02c06
- L2
- wu:fl02c06
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable ephrin receptor binding activity. Predicted to be involved in several processes, including axon guidance; ephrin receptor signaling pathway; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in side of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including anterior neural keel; immature eye; nervous system; neural plate; and neural tube. Orthologous to human EFNA5 (ephrin A5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1080 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014000Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014001Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021866Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028316Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cupredoxin | Ephrin | Ephrin-A ectodomain | Ephrin, conserved site | Ephrin receptor-binding domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B861 | InterPro | 202 | |||||
| UniProtKB:A0A8M1PZ39 | InterPro | 227 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
efna5a-201
(1)
|
Ensembl | 4,685 nt | ||
| mRNA |
efna5a-202
(1)
|
Ensembl | 555 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-22D5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-6O9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-30K6 | ZFIN Curated Data | |
| Encodes | EST | cb1080 | Thisse et al., 2001 | |
| Encodes | EST | fl02c06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001337352 (1) | 1921 nt | ||
| Genomic | GenBank:AL844141 (1) | 257634 nt | ||
| Polypeptide | UniProtKB:A0A8M1PZ39 (1) | 227 aa |
- Hernández-Bejarano, M., Gestri, G., Monfries, C., Tucker, L., Dragomir, E.I., Bianco, I.H., Bovolenta, P., Wilson, S.W., Cavodeassi, F. (2022) Foxd1-dependent induction of a temporal retinal character is required for visual function. Development (Cambridge, England). 149(24):
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Zhang, J.F., Jiang, Z., Liu, X., Meng, A. (2016) Eph-ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development (Cambridge, England). 143(14):2603-15
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liao, W.H., Cheng, C.H., Hung, K.S., Chiu, W.T., Chen, G.D., Hwang, P.P., Hwang, S.P., Kuan, Y.S., and Huang, C.J. (2013) Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling. Cellular and molecular life sciences : CMLS. 70(13):2367-81
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Erickson, T., French, C.R., and Waskiewicz, A.J. (2010) Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system. Neural Development. 5:22
- Ye, M., Berry-Wynne, K.M., Asai-Coakwell, M., Sundaresan, P., Footz, T., French, C.R., Abitbol, M., Fleisch, V.C., Corbett, N., Allison, W.T., Drummond, G., Walter, M.A., Underhill, T.M., Waskiewicz, A.J., and Lehmann, O.J. (2010) Mutation of the Bone Morphogenetic Protein GDF3 causes ocular and skeletal anomalies. Human molecular genetics. 19(2):287-298
- McMahon, C., Gestri, G., Wilson, S.W., and Link, B.A. (2009) Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish. Developmental Biology. 332(2):287-298
- Picker, A., Cavodeassi, F., Machate, A., Bernauer, S., Hans, S., Abe, G., Kawakami, K., Wilson, S.W., and Brand, M. (2009) Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina. PLoS Biology. 7(10):e1000214
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