Gene
star
- ID
- ZDB-GENE-001120-3
- Name
- steroidogenic acute regulatory protein
- Symbol
- star Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol binding activity. Acts upstream of or within oocyte maturation. Predicted to be located in mitochondrion. Is expressed in endocrine system; forebrain; interrenal primordium; male organism; and reproductive system. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Shang et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb350 | Allele with one deletion | Exon 2 | Unknown | TALEN | |
| la029493Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa31674 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital adrenal hyperplasia | Alliance | Lipoid adrenal hyperplasia | 201710 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | START domain | START-like domain superfamily | Steroidogenic acute regulatory protein | Steroidogenic acute regulatory protein-like |
|---|---|---|---|---|---|---|
| UniProtKB:Q9DG10 | InterPro | 285 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2star:bPAC-2A-Tomato) |
|
| 2 | (4) | |
| Tg(-2star:GFP,myl7:RFP) |
|
| 1 | (2) | |
| Tg(-2star:NTR-GFP,myl7:RFP) |
|
| 1 | Arturo Gutierrez-Triana et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-322G6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92258 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131663 (1) | 1291 nt | ||
| Genomic | GenBank:CU861510 (2) | 87215 nt | ||
| Polypeptide | UniProtKB:Q9DG10 (1) | 285 aa |
- Ahmad, A., Bogoch, Y., Shvaizer, G., Guler, N., Levy, K., Elkouby, Y.M. (2025) The piRNA protein Asz1 is essential for germ cell and gonad development in zebrafish and exhibits differential necessities in distinct types of germ granules. PLoS Genetics. 21:e1010868e1010868
- Shi, C., Zhang, Y., Lu, Y., Lou, Q., Shang, G., Peng, X., Dai, X., Jin, X., He, J., Zhai, G., Yin, Z. (2025) Insights into the role of Fsh signaling in ovarian differentiation of chorionic gonadotropin α ( cgα)-deficient zebrafish. Zoological research. 46:695708695-708
- Castillo-Ramírez, L.A., Herget, U., Ryu, S., De Marco, R.J. (2024) Early-life challenge enhances cortisol regulation in zebrafish larvae. Biology Open. 13(12):
- Li, C., Cai, R., Shi, W., Zhang, H., Liu, Z., Xie, F., Chen, Y., Hong, Q. (2024) Comparative transcriptome analysis of ovaries and testes reveals sex-biased genes and pathways in zebrafish. Gene. 901:148176
- Rajeswari, J.J., Faught, E., Santos, H., Vijayan, M.M. (2024) Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin. Journal of Cellular Physiology. 239(12):e31428
- Uju, C., Karimzadeh, K., Unniappan, S. (2024) Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 169(1):
- Yu, Y., Tanaka, S., Wong, T.T., Zohar, Y., Zmora, N. (2024) Loss of function of Vasoactive-intestinal peptide alters sex ratio and reduces male reproductive fitness in zebrafish. Endocrinology. 165(8):
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Herget, U., Ryu, S., De Marco, R.J. (2023) Altered glucocorticoid reactivity and behavioral phenotype in rx3-/- larval zebrafish. Frontiers in endocrinology. 14:11873271187327
- Arab-Bafrani, Z., Zabihi, E., Hoseini, S.M., Sepehri, H., Khalili, M. (2022) Silver nanoparticles modify hypothalamic-pituitary-interrenal axis and block cortisol response to an acute stress in zebrafish, Danio rerio. Toxicology and industrial health. 38(4):201-209
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