Gene
pax5
- ID
- ZDB-GENE-001030-2
- Name
- paired box 5
- Symbol
- pax5 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within vestibular receptor cell development and vestibular reflex. Predicted to be located in nucleus. Is expressed in several structures, including chordo neural hinge; hindbrain neural keel; immune system; midbrain hindbrain boundary neural keel; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human PAX5 (paired box 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 52 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu596 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Kwak et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16357 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19482 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| x84 | Allele with one deletion | Exon 3 | Unknown | TALEN | |
| zko418a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko418b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pax5 | (2) | |
| CRISPR2-pax5 | Zapilko et al., 2023 | |
| CRISPR3-pax5 | Zapilko et al., 2023 | |
| MO1-pax5 | N/A | Kwak et al., 2006 |
| MO2-pax5 | N/A | Kwak et al., 2006 |
| MO3-pax5 | N/A | Kwak et al., 2006 |
| MO4-pax5 | N/A | Kwak et al., 2006 |
| MO5-pax5 | N/A | Kwak et al., 2006 |
| TALEN1-pax5 | Roberson et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Leukemia, acute lymphoblastic, susceptibility to, 3} | 615545 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Paired-box protein 2 C-terminal | Paired DNA-binding domain | Paired domain | PAX family | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BI63 | InterPro | 423 | ||||||
| UniProtKB:F1QGF8 | InterPro | 396 | ||||||
| UniProtKB:A0A8M2BI96 | InterPro | 422 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-134C9 | ZFIN Curated Data | |
| Encodes | EST | eu596 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131638 (1) | 11716 nt | ||
| Genomic | GenBank:BX511134 (2) | 188290 nt | ||
| Polypeptide | UniProtKB:A0A8M2BI63 (1) | 423 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Park, G., Foster, C.A., Malone-Perez, M., Hasan, A., Macias, J.J., Frazer, J.K. (2024) Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method. Journal of immunology (Baltimore, Md. : 1950). 213(12):1902-1914
- Roberson, W., Holland, J.N., Riley, B.B. (2024) Pax2a, Pax5 and Cdh1-β-catenin, but not Wnt, protect sensory hair cells from destabilizing effects of Fgf signaling on cell adhesion. Developmental Biology. 517:157-167
- Zhao, S., Mo, G., Wang, Q., Xu, J., Yu, S., Huang, Z., Liu, W., Zhang, W. (2024) Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. 10:182182
- Cardoso, B.A., Duque, M., Gírio, A., Fragoso, R., Oliveira, M.L., Allen, J.R., Martins, L.R., Correia, N.C., Silveira, A.B., Veloso, A., Kimura, S., Demoen, L., Matthijssens, F., Jeha, S., Cheng, C., Pui, C.H., Grosso, A.R., Neto, J.L., De Almeida, S.F., Van Vlieberghe, P., Mullighan, C.G., Yunes, J.A., Langenau, D.M., Pflumio, F., Barata, J.T. (2023) CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia. Haematologica. 109(6):1713-1725
- Leino, S.A., Constable, S.C.J., Streit, A., Wilkinson, D.G. (2023) Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain. Development (Cambridge, England). 150(18):
- Madushani, K.P., Shanaka, K.A.S.N., Jung, S., Kim, M.J., Lee, J. (2023) Ablation of myd88 alters the immune gene expression and immune cell recruitment during VHSV infection in zebrafish. Fish & shellfish immunology. 141:109006
- Rothschild, S.C., Lai, G., Tombes, R.M., Clements, W.K. (2023) Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish. PLoS Genetics. 19:e1011102e1011102
- Wang, D., Zheng, L., Cheng, B.Y.L., Sin, C.F., Li, R., Tsui, S.P., Yi, X., Ma, A.C.H., He, B.L., Leung, A.Y.H., Sun, X. (2023) Transgenic IDH2R172K and IDH2R140Q zebrafish models recapitulated features of human acute myeloid leukemia. Oncogene. 42(16):1272-1281
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