Gene

fgf4

ID
ZDB-GENE-001006-1
Name
fibroblast growth factor 4
Symbol
fgf4 Nomenclature History
Previous Names
  • fc89b01
  • id:ibd5158
  • wu:fc89b01
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including Kupffer's vesicle development; Spemann organizer formation at the embryonic shield; and paraxial mesoderm development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including brain; fin bud; notochord; pharynx; and tail bud. Orthologous to human FGF4 (fibroblast growth factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
32 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
zf3997Allele with one deletionExon 1UnknownCRISPR
1 - 1 of 1
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Sequence Targeting Reagents
1 - 6 of 6
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Human Disease
Associated With fgf4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Short-rib thoracic dysplasia 22 without polydactyly 621260
1 - 1 of 1
Associated With fgf4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002209 Fibroblast growth factor family
Homologous_superfamily IPR008996 Cytokine IL1/FGF
1 - 2 of 2
Domain Details Per Protein
Protein Additional Resources Length Cytokine IL1/FGF Fibroblast growth factor family
UniProtKB:Q9DFC9 InterPro 191
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 7
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fgf4-201 (1) Ensembl 3,170 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-188I17
EncodesESTeu142
    Thisse et al., 2005
    EncodesESTfc89b01
    EncodesESTibd5158
    EncodescDNAMGC:158215ZFIN Curated Data
    1 - 5 of 5
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanFGF411
    Amino acid sequence comparison (2)
    Conserved genome location (synteny) (3)
    MouseFgf47
    Conserved genome location (synteny) (1)
    Citations
    1 - 10 of 43
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