Gene

fech

ID

ZDB-GENE-000928-1

Name

ferrochelatase

Symbol

fech Nomenclature History

Previous Names

fch (1)
dracula
drc
frx
zgc:109851

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Enables ferrochelatase activity. Acts upstream of or within erythrocyte maturation. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in blood; intermediate cell mass of mesoderm; kidney; posterior lateral plate mesoderm; and ventral mesoderm. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109851 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fech Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
erythropoietic protoporphyria	Alliance	Protoporphyria, erythropoietic, 1	177000

Associated With fech Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR019772	Ferrochelatase, active site
Domain	IPR033644	Ferrochelatase, C-terminal
Domain	IPR033659	Ferrochelatase, N-terminal
Family	IPR001015	Ferrochelatase