Gene
fech
- ID
- ZDB-GENE-000928-1
- Name
- ferrochelatase
- Symbol
- fech Nomenclature History
- Previous Names
-
- fch (1)
- dracula
- drc
- frx
- zgc:109851
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables ferrochelatase activity. Acts upstream of or within erythrocyte maturation. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in blood; intermediate cell mass of mesoderm; kidney; posterior lateral plate mesoderm; and ventral mesoderm. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109851 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| m87 | unknown | Unknown | Unknown | ENU | |
| m159 | unknown | Unknown | Unknown | ENU | |
| m248 | Allele with one point mutation | Donor Splice Site | Unknown | ENU | |
| m328 | unknown | Unknown | Unknown | ENU | |
| sa23835 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37199 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tu271 | unknown | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fech | Wijerathna et al., 2024 | |
| MO1-fech | N/A | (2) |
| MO2-fech | N/A | Sumanas et al., 2002 |
| MO3-fech | N/A | Gupta et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| erythropoietic protoporphyria | Alliance | Protoporphyria, erythropoietic, 1 | 177000 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ferrochelatase | Ferrochelatase, active site | Ferrochelatase, C-terminal | Ferrochelatase, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PIE9 | InterPro | 409 | ||||
| UniProtKB:Q9DFU9 | InterPro | 409 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-334H6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109851 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191894 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131631 (1) | 1402 nt | ||
| Genomic | GenBank:FP245523 (2) | 34475 nt | ||
| Polypeptide | UniProtKB:A0A8M9PIE9 (1) | 409 aa |
- Wijerathna, H.M.S.M., Shanaka, K.A.S.N., Raguvaran, S.S., Jayamali, B.P.M.V., Kim, S.H., Kim, M.J., Jung, S., Lee, J. (2024) CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening. International Journal of Molecular Sciences. 25(19):
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Chen, X., Li, W. (2021) Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio). The Science of the total environment. 787:147529
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Park, J., Belden, W.J. (2018) Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin. BMC Genomics. 19:777
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Zhou, Z.J., Sun, L. (2016) Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Frontiers in cellular and infection microbiology. 6:76
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yang, R., Yan, S., Zhu, X., Li, C.Y., Liu, Z., Xiong, J.W. (2015) Antimalarial drug artemisinin depletes erythrocytes by activating apoptotic pathways in zebrafish. Experimental hematology. 43(4):331-341.e8
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