Gene
hoxa9b
- ID
- ZDB-GENE-000823-2
- Name
- homeobox A9b
- Symbol
- hoxa9b Nomenclature History
- Previous Names
-
- Hoxa-9
- zgc:110504
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic skeletal system morphogenesis; regionalization; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA-templated transcription and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; chondroblast; fin; pectoral fin bud; and pectoral fin field. Orthologous to human HOXA9 (homeobox A9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb430 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb431 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la027699Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6422 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sud165a | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hoxa9b | Zebrafish Nomenclature Committee | |
| CRISPR2-hoxa9b | Adachi et al., 2024 | |
| MO1-hoxa9b | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Abd-B homeobox transcription factor | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein HXA9/HXB9/HXC9 | Homeodomain | Homeodomain, metazoa | Hox9, N-terminal activation domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QQN5 | InterPro | 253 | |||||||
| UniProtKB:Q9YGT5 | InterPro | 253 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxa9b-201
(1)
|
Ensembl | 1,495 nt | ||
| mRNA | ottdart00000001849 (1) | Havana | 726 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-45E15 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-31B14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110504 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131533 (1) | 777 nt | ||
| Genomic | GenBank:CR392024 (1) | 183486 nt | ||
| Polypeptide | UniProtKB:F1QQN5 (1) | 253 aa |
- Adachi, U., Koita, R., Seto, A., Maeno, A., Ishizu, A., Oikawa, S., Tani, T., Ishizaka, M., Yamada, K., Satoh, K., Nakazawa, H., Furudate, H., Kawakami, K., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins. Proceedings of the National Academy of Sciences of the United States of America. 121:e2403809121e2403809121
- Ishizaka, M., Maeno, A., Nakazawa, H., Fujii, R., Oikawa, S., Tani, T., Kanno, H., Koita, R., Kawamura, A. (2024) The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development. Scientific Reports. 14:2360223602
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Albert, L., Nagpal, J., Steinchen, W., Zhang, L., Werel, L., Djokovic, N., Ruzic, D., Hoffarth, M., Xu, J., Kaspareit, J., Abendroth, F., Royant, A., Bange, G., Nikolic, K., Ryu, S., Dou, Y., Essen, L.O., Vázquez, O. (2022) Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. ACS central science. 8:57-66
- Smeeton, J., Natarajan, N., Naveen Kumar, A., Miyashita, T., Baddam, P., Fabian, P., Graf, D., Crump, J.G. (2021) Zebrafish Model for Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Reveals Post-Embryonic Roles of Nkx3.2 in the Skeleton. Development (Cambridge, England). 148(2):
- Soto, R.A., Najia, M.A.T., Hachimi, M., Frame, J.M., Yette, G.A., Lummertz da Rocha, E., Stankunas, K., Daley, G.Q., North, T.E. (2021) Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports. 16(7):1718-1734
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Rougeot, J., Chrispijn, N.D., Aben, M., Elurbe, D.M., Andralojc, K.M., Murphy, P.J., Jansen, P.W.T.C., Vermeulen, M., Cairns, B.R., Kamminga, L.M. (2019) Maintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan. Development (Cambridge, England). 146(19):
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Payumo, A.Y., McQuade, L.E., Walker, W.J., Yamazoe, S., Chen, J.K. (2016) Tbx16 regulates hox gene activation in mesodermal progenitor cells. Nature Chemical Biology. 12(9):694-701
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