Gene
mxtx1
- ID
- ZDB-GENE-000710-7
- Name
- mix-type homeobox gene 1
- Symbol
- mxtx1 Nomenclature History
- Previous Names
-
- mtx1
- sb:cb779 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic heart tube development; positive regulation of DNA-templated transcription; and somite specification. Predicted to be active in nucleus. Is expressed in yolk syncytial layer. Orthologous to human DUX4 (double homeobox 4) and DUX4L9 (double homeobox 4 like 9 (pseudogene)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb779 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mxtx1 | N/A | (2) |
| MO2-mxtx1 | N/A | Sakaguchi et al., 2006 |
| MO3-mxtx1 | N/A | Sakaguchi et al., 2006 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox domain-containing regulator | Homeodomain |
|---|---|---|---|---|---|
| UniProtKB:A0JPE5 | InterPro | 309 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-191G9 | ZFIN Curated Data | |
| Contains | STS | chunp30149 | ||
| Encodes | EST | cb779 | (2) | |
| Encodes | cDNA | MGC:152852 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131560 (1) | 1867 nt | ||
| Genomic | GenBank:CT573412 (1) | 171391 nt | ||
| Polypeptide | UniProtKB:A0JPE5 (1) | 309 aa |
No data available
- Dogra, D., Ahuja, S., Kim, H.T., Rasouli, S.J., Stainier, D.Y.R., Reischauer, S. (2017) Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair. Nature communications. 8:1902
- Nakayama, Y., Inomata, C., Yuikawa, T., Tsuda, S., Yamasu, K. (2017) Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis. Developmental Biology. 430(1):237-248
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Lee, M.T., Bonneau, A.R., Takacs, C.M., Bazzini, A.A., Divito, K.R., Fleming, E.S., and Giraldez, A.J. (2013) Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature. 503(7476):360-4
- Chu, L.T., Fong, S.H., Kondrychyn, I., Loh, S.L., Ye, Z., and Korzh, V. (2012) Yolk syncytial layer formation is a failure of cytokinesis mediated by Rock1 function in the early zebrafish embryo. Biology Open. 1(8):747-753
- Langenbacher, A.D., Huang, J., Chen, Y., and Chen, J.N. (2012) Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis. Developmental Biology. 362(2):263-270
- Pereira, L.A., Wong, M.S., Mei Lim, S., Stanley, E.G., and Elefanty, A.G. (2012) The Mix family of homeobox genes - key regulators of mesendoderm formation during vertebrate development. Developmental Biology. 367(2):163-177
- Hong, S.K., Levin, C.S., Brown, J.L., Wan, H., Sherman, B.T., Huang, D.W., Lempicki, R.A., and Feldman, B. (2010) Pre-gastrula expression of zebrafish extraembryonic genes. BMC Developmental Biology. 10:42
- Arrington, C.B., and Yost, H.J. (2009) Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo. Development (Cambridge, England). 136(18):3143-3152
- Sakaguchi, T., Kikuchi, Y., Kuroiwa, A., Takeda, H., and Stainier, D.Y. (2006) The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish. Development (Cambridge, England). 133(20):4063-4072
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