Gene
ngfb
- ID
- ZDB-GENE-000629-2
- Name
- nerve growth factor b (beta polypeptide)
- Symbol
- ngfb Nomenclature History
- Previous Names
-
- NGF
- ngf
- ngfb (1)
- ns:zft386
- xx:zft386
- zgc:109730
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of neuron apoptotic process; and nervous system development. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including alar plate midbrain region; gonad; kidney; nervous system; and periderm. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and opiate dependence (multiple). Orthologous to human NGF (nerve growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109730 (16 images)
- eu513 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 5 | Alliance | Neuropathy, hereditary sensory and autonomic, type V | 608654 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Nerve growth factor conserved site | Nerve growth factor-like | Nerve growth factor-related |
|---|---|---|---|---|---|---|
| UniProtKB:Q6YBR5 | InterPro | 194 | ||||
| UniProtKB:A0A8M1PAS0 | InterPro | 224 | ||||
| UniProtKB:B2GR51 | InterPro | 194 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-105J21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-183K8 | ZFIN Curated Data | |
| Encodes | EST | eu513 | Thisse et al., 2005 | |
| Encodes | EST | zft386 | ||
| Encodes | cDNA | MGC:109730 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192168 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199210 (1) | 1683 nt | ||
| Genomic | GenBank:BX950174 (1) | 170278 nt | ||
| Polypeptide | UniProtKB:A0A8M1PAS0 (1) | 224 aa |
- Liu, Y., Zhu, Y., Wang, X., Li, Y., Yang, S., Li, H., Dong, B., Wang, Z., Song, Y., Xu, J., Xue, C. (2025) Mechanisms by which Ganglioside GM1, a specific type of glycosphingolipid, ameliorates BMAA-induced neurotoxicity in early-life stage of zebrafish embryos. Food research international (Ottawa, Ont.). 200:115502115502
- Cacialli, P. (2022) Expression of Nerve Growth Factor and Its Receptor TrkA in the Reproductive System of Adult Zebrafish. Veterinary sciences. 9(5)
- Cacialli, P., Lucini, C. (2022) Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney. Veterinary sciences. 9(6)
- Jeong, I., Yun, S., Shahapal, A., Cho, E.B., Hwang, S.W., Seong, J.Y., Park, H.C. (2021) FAM19A5l Affects Mustard Oil-Induced Peripheral Nociception in Zebrafish. Molecular neurobiology. 58(9):4770-4785
- Barui, A.K., Jhelum, P., Nethi, S.K., Das, T., Bhattacharya, D., B, V., Karri, S., Chakravarty, S., Patra, C.R. (2020) Potential Therapeutic Application of Zinc Oxide Nanoflowers in the Cerebral Ischemia Rat Model through Neuritogenic and Neuroprotective Properties. Bioconjugate Chemistry. 31:895-906
- Das, T., Soren, K., Yerasi, M., Kamle, A., Kumar, A., Chakravarty, S. (2020) Molecular Basis of Sex Difference in Neuroprotection induced by Hypoxia Preconditioning in Zebrafish. Molecular neurobiology. 57(12):5177-5192
- Cacialli, P., Gatta, C., D'Angelo, L., Leggieri, A., Palladino, A., de Girolamo, P., Pellegrini, E., Lucini, C. (2019) Nerve growth factor is expressed and stored in central neurons of adult zebrafish. Journal of anatomy. 235(1):167-179
- Khazaee, M., Guardian, M.G.E., Aga, D.S., Ng, C.A. (2019) Impacts of sex and exposure duration on gene expression in zebrafish following perfluorooctane sulfonate (PFOS) exposure. Environmental toxicology and chemistry. 39(2):437-449
- Nittoli, V., Sepe, R.M., Coppola, U., D'Agostino, Y., De Felice, E., Palladino, A., Vassalli, Q.A., Locascio, A., Ristoratore, F., Spagnuolo, A., D'Aniello, S., Sordino, P. (2018) A comprehensive analysis of neurotrophins and neurotrophin tyrosine kinase receptors expression during development of zebrafish. The Journal of comparative neurology. 526(6):1057-1072
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
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