Gene
adarb1a
- ID
- ZDB-GENE-000627-2
- Name
- adenosine deaminase RNA specific B1a
- Symbol
- adarb1a Nomenclature History
- Previous Names
-
- ADAR2 (1)
- adarb1
- RED1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; lateral line development; and neural crest cell development. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. Is expressed in several structures, including ceratobranchial cartilage; fin bud; nervous system; neural plate; and pericardial region. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu111 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014151Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14549 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37456 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-adarb1a | N/A | Li et al., 2014 |
| MO2-adarb1a | N/A | Li et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with hypotonia, microcephaly, and seizures | 618862 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAR2, first double-stranded RNA binding domain | ADAR2, second double-stranded RNA binding domain | Adenosine deaminase/editase | Double-stranded RNA-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P669 | InterPro | 720 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adarb1a-201
(1)
|
Ensembl | 5,959 nt | ||
| mRNA |
adarb1a-202
(1)
|
Ensembl | 5,944 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-170G11 | ZFIN Curated Data | |
| Encodes | EST | eu111 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131610 (1) | 5967 nt | ||
| Genomic | GenBank:CR847870 (1) | 237985 nt | ||
| Polypeptide | UniProtKB:A0A8M1P669 (1) | 720 aa |
- Niescierowicz, K., Pryszcz, L., Navarrete, C., Tralle, E., Sulej, A., Abu Nahia, K., Kasprzyk, M.E., Misztal, K., Pateria, A., Pakuła, A., Bochtler, M., Winata, C. (2022) Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish. Nature communications. 13:5520
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shamay-Ramot, A., Khermesh, K., Porath, H.T., Barak, M., Pinto, Y., Wachtel, C., Zilberberg, A., Lerer-Goldshtein, T., Efroni, S., Levanon, E.Y., Appelbaum, L. (2015) Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. PLoS Genetics. 11:e1005702
- Li, I.C., Chen, Y.C., Wang, Y.Y., Tzeng, B.W., Ou, C.W., Lau, Y.Y., Wu, K.M., Chan, T.M., Lin, W.H., Hwang, S.P., Chow, W.Y. (2014) Zebrafish Adar2 Edits the Q/R Site of AMPA Receptor Subunit gria2alpha Transcript to Ensure Normal Development of Nervous System and Cranial Neural Crest Cells. PLoS One. 9:e97133
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Slavov, D. and Gardiner, K. (2002) Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns. Gene. 299(1-2):83-94
- Slavov, D., Clark, M., and Gardiner, K. (2000) Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish. Gene. 250(1-2):41-51
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