Gene
myf5
- ID
- ZDB-GENE-000616-6
- Name
- myogenic factor 5
- Symbol
- myf5 Nomenclature History
- Previous Names
-
- myf-5
- cb641 (1)
- zgc:110509
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including chordate pharyngeal muscle development; neural crest cell development; and skeletal muscle tissue development. Located in nucleolus and nucleoplasm. Is expressed in several structures, including mesoderm; musculature system; myoblast; pharyngeal arch; and post-vent region. Orthologous to human MYF5 (myogenic factor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 100 figures from 63 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb641 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-myf5 | N/A | (8) |
| MO3-myf5 | N/A | (12) |
| MO4-myf5 | N/A | Chong et al., 2007 |
| MO5-myf5 | N/A | Maves et al., 2007 |
| MO6-myf5 | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ophthalmoplegia, external, with rib and vertebral anomalies | 618155 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002546 | Myogenic muscle-specific protein, N-terminal |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR022032 | Myogenic determination factor 5 |
| Family | IPR039704 | Myogenic factor |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Myogenic determination factor 5 | Myogenic factor | Myogenic muscle-specific protein, N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DDW0 | InterPro | 237 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2.4myf5:EGFP) |
|
| 1 | (4) | |
| Tg(-10.0myf5:EGFP) |
|
| 1 | (11) | |
| Tg(-80.0myf5:EGFP) |
|
| 1 | (10) | |
| Tg(AITR-0.3myf5:EGFP) |
|
| 1 | (2) | |
| Tg(AITR-3.0myf5:EGFP) |
|
| 1 | (3) | |
| Tg(AITR-6.0myf5:EGFP) |
|
| 1 | (3) | |
| Tg(AITR-10.0myf5:EGFP) |
|
| 1 | (2) | |
| Tg(myf5:EGFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-91G3 | ZFIN Curated Data | |
| Encodes | EST | cb641 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:110509 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192249 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131576 (1) | 1433 nt | ||
| Genomic | GenBank:BX537156 (1) | 117987 nt | ||
| Polypeptide | UniProtKB:Q9DDW0 (1) | 237 aa |
- Donaka, R., Zheng, H., Ackert-Bicknell, C.L., Karasik, D. (2024) Early life lipid overload in Native American Myopathy is phenocopied by stac3 knockout in zebrafish. Gene. 936:149123
- Hsu, T.C., Chiang, C.H., Liu, I.H., Wang, C.Y., Chen, C.Y. (2024) Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish. International Journal of Molecular Sciences. 25(23):
- Paulissen, E., Martin, B.L. (2024) A Chemically Inducible Muscle Ablation System for the Zebrafish. Zebrafish. 21(3):243-249
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zhou, C., Li, M., Sun, Y., Sultan, Y., Li, X. (2024) Systematic Identification of Long Noncoding RNAs during Three Key Organogenesis Stages in Zebrafish. International Journal of Molecular Sciences. 25(6):
- Zizioli, D., Codenotti, S., Benaglia, G., Manzoni, M., Massardi, E., Fanzani, A., Borsani, G., Monti, E. (2023) Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development. International Journal of Molecular Sciences. 24(17):
- Paulissen, E., Martin, B.L. (2022) Myogenic regulatory factors myod and Myf5 are required for dorsal aorta formation and angiogenic sprouting. Developmental Biology. 490:134-143
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Bian, W.P., Pu, S.Y., Xie, S.L., Wang, C., Deng, S., Strauss, P.R., Pei, D.S. (2021) Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish. Cell death discovery. 7:250
- Lanes, C.F.C., Pedron, F.A., Bergamin, G.T., Bitencourt, A.L., Dorneles, B.E.R., Villanova, J.C.V., Dias, K.C., Riolo, K., Oliva, S., Savastano, D., Giannetto, A. (2021) Black Soldier Fly (Hermetia illucens) Larvae and Prepupae Defatted Meals in Diets for Zebrafish (Danio rerio). Animals : an open access journal from MDPI. 11(3):
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