Gene
adar
- ID
- ZDB-GENE-000616-5
- Name
- adenosine deaminase RNA specific
- Symbol
- adar Nomenclature History
- Previous Names
-
- drada
- red1
- wu:fc22a02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Acts upstream of or within anterior/posterior axis specification, embryo. Predicted to be active in cytoplasm and nucleolus. Is expressed in brain and nervous system. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu29 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Niescierowicz et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa817 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6428 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16847 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18476 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22832 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| waw104 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adar | Niescierowicz et al., 2022 | |
| MO1-adar | N/A | Kasher et al., 2015 |
| MO2-adar | N/A | Kasher et al., 2015 |
| MO3-adar | N/A | Niescierowicz et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aicardi-Goutieres syndrome | Alliance | Aicardi-Goutieres syndrome 6 | 615010 |
| dyschromatosis symmetrica hereditaria | Alliance | Dyschromatosis symmetrica hereditaria | 127400 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002466 | Adenosine deaminase/editase |
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR042371 | Z-binding domain |
| Domain | IPR044456 | ADAR1, first double-stranded RNA binding domain |
| Domain | IPR044457 | ADAR1, third double-stranded RNA binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ADAR1, first double-stranded RNA binding domain | ADAR1, third double-stranded RNA binding domain | Adenosine deaminase/editase | Double-stranded RNA-binding domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Z-binding domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P8J0 | InterPro | 1381 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-216F21 | ZFIN Curated Data | |
| Encodes | EST | eu29 | Thisse et al., 2005 | |
| Encodes | EST | fc22a02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55234 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131596 (1) | 7238 nt | ||
| Genomic | GenBank:CR533578 (1) | 214872 nt | ||
| Polypeptide | UniProtKB:A0A8M1P8J0 (1) | 1381 aa |
- Niescierowicz, K., Pryszcz, L., Navarrete, C., Tralle, E., Sulej, A., Abu Nahia, K., Kasprzyk, M.E., Misztal, K., Pateria, A., Pakuła, A., Bochtler, M., Winata, C. (2022) Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish. Nature communications. 13:5520
- Sánchez, E., Azcona, L.J., Paisán-Ruiz, C. (2018) Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Molecular neurobiology. 55(8):6734-6754
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kasher, P.R., Jenkinson, E.M., Briolat, V., Gent, D., Morrissey, C., Zeef, L.A., Rice, G.I., Levraud, J.P., Crow, Y.J. (2015) Characterization of samhd1 Morphant Zebrafish Recapitulates Features of the Human Type I Interferonopathy Aicardi-Goutières Syndrome. Journal of immunology (Baltimore, Md. : 1950). 194(6):2819-25
- Shamay-Ramot, A., Khermesh, K., Porath, H.T., Barak, M., Pinto, Y., Wachtel, C., Zilberberg, A., Lerer-Goldshtein, T., Efroni, S., Levanon, E.Y., Appelbaum, L. (2015) Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. PLoS Genetics. 11:e1005702
- Sun, Z., Wang, B., Liu, Y., Liu, X., Mi, Y., Gu, M., Wang, F., Wu, C., Hu, C. (2015) Genome organization and transcriptional regulation of Adenosine Deaminase Acting on RNA gene 1 (ADAR1) in grass carp (Ctenopharyngodon idella). Developmental and comparative immunology. 50(2):98-105
- Wang, Y., Yang, L., Zhou, K., Zhang, Y., Song, Z., He, S. (2015) Evidence for adaptation to the Tibetan Plateau inferred from Tibetan loach transcriptomes. Genome biology and evolution. 7(11):2970-82
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Li, I.C., Chen, Y.C., Wang, Y.Y., Tzeng, B.W., Ou, C.W., Lau, Y.Y., Wu, K.M., Chan, T.M., Lin, W.H., Hwang, S.P., Chow, W.Y. (2014) Zebrafish Adar2 Edits the Q/R Site of AMPA Receptor Subunit gria2alpha Transcript to Ensure Normal Development of Nervous System and Cranial Neural Crest Cells. PLoS One. 9:e97133
- Sieger, D., Stein, C., Neifer, D., van der Sar, A.M., and Leptin, M. (2009) The role of gamma interferon in innate immunity in the zebrafish embryo. Disease models & mechanisms. 2(11-12):571-581
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