Gene

hey2

ID
ZDB-GENE-000526-1
Name
hes-related family bHLH transcription factor with YRPW motif 2
Symbol
hey2 Nomenclature History
Previous Names
  • gridlock (1)
  • grl (1)
  • Herp2 (1)
  • zgc:136746 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a positive effect on cardiac muscle cell proliferation. Acts upstream of or within cardiac muscle tissue regeneration; circulatory system development; and negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; hematopoietic system; mesoderm; and nervous system. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
76 figures from 62 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hsc25Allele with one deletionExon 2UnknownCRISPR
hsc27TgTransgenic insertionUnknownUnknownDNA and CRISPR
ihb463Allele with one insertionExon 4UnknownCRISPR
ihb464Allele with one deletionExon 4UnknownCRISPR
m145Allele with one point mutationUnknownMissenseENU
sa10785Allele with one point mutationUnknownSplice SiteENU
sa16273Allele with one point mutationUnknownPremature StopENU
sa23783Allele with one point mutationUnknownPremature StopENU
sa29430Allele with one point mutationUnknownPremature StopENU
um216Allele with one deletionUnknownFrameshift, Premature StopCRISPR
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Sequence Targeting Reagents
1 - 9 of 9
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Human Disease
Associated With hey2 Human Ortholog
No data available
Associated With hey2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003650 Orange domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Family IPR050370 Hairy and Enhancer of Split/HEY-related
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Hairy and Enhancer of Split/HEY-related Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Orange domain
UniProtKB:Q9I9L0 InterPro 324
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA hey2-201 (1) Ensembl 1,816 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-hey2-LOXP-gata2a:EGFP-5HS4)
  • Danio rerio
  • Xenopus laevis
3 (3)
Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-hey2-LOXP-gata2a:EGFP-5HS4)
  • Danio rerio
  • Xenopus laevis
3 (3)
Tg(hey2:EGFP)
  • hey2
  • Danio rerio
1She et al., 2020
Tg(hey2:mCherry)
  • hey2
  • Danio rerio
1She et al., 2020
Tg(myl7:LOXP-NLS-mCherry-LOXP-hey2-EGFP)
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-172B22ZFIN Curated Data
EncodesESTeu521Thisse et al., 2005
EncodescDNAMGC:136746ZFIN Curated Data
EncodescDNAMGC:194026ZFIN Curated Data
EncodescDNAMGC:194033ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanHEY26
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
MouseHey210
Amino acid sequence comparison (1)
Citations
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