Gene
p2rx3a
- ID
- ZDB-GENE-000427-3
- Name
- purinergic receptor P2X, ligand-gated ion channel, 3a
- Symbol
- p2rx3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables extracellularly ATP-gated monoatomic cation channel activity. Acts upstream of or within monoatomic cation transport and neurogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head and nervous system. Orthologous to human P2RX3 (purinergic receptor P2X 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Kucenas et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-p2rx3a | N/A | Kucenas et al., 2009 |
| MO2-p2rx3a | N/A | Kucenas et al., 2009 |
| MO3-p2rx3a | N/A | Kucenas et al., 2009 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP P2X receptor, conserved site | P2X3 purinoceptor | P2X purinoreceptor | P2X purinoreceptor extracellular domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q9I8N8 | InterPro | 410 | ||||
| UniProtKB:A0A8M1PBR7 | InterPro | 410 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
p2rx3a-201
(1)
|
Ensembl | 3,586 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-10K1 | ZFIN Curated Data | |
| Encodes | EST | fb99b08 | ||
| Encodes | cDNA | MGC:193876 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193884 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131623 (1) | 1695 nt | ||
| Genomic | GenBank:BX324205 (1) | 168546 nt | ||
| Polypeptide | UniProtKB:A0A8M1PBR7 (1) | 410 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | P2RX3 | 11 | Amino acid sequence comparison (1) |
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Medrano, M.P., Bejarano, C.A., Battista, A.G., Venera, G.D., Bernabeu, R.O., Faillace, M.P. (2017) Injury-induced purinergic signalling molecules upregulate pluripotency gene expression and mitotic activity of progenitor cells in the zebrafish retina. Purinergic signalling. 13(4):443-465
- Zada, D., Tovin, A., Lerer-Goldshtein, T., Vatine, G.D., Appelbaum, L. (2014) Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation. PLoS Genetics. 10:e1004615
- Palanca, A.M., Lee, S.L., Yee, L.E., Joe-Wong, C., Trinh, L.A., Hiroyasu, E., Husain, M., Fraser, S.E., Pellegrini, M., and Sagasti, A. (2013) New transgenic reporters identify somatosensory neuron subtypes in larval zebrafish. Developmental Neurobiology. 73(2):152-167
- Kucenas, S., Cox, J.A., Soto, F., Lamora, A., and Voigt, M.M. (2009) Ectodermal P2X receptor function plays a pivotal role in craniofacial development of the zebrafish. Purinergic signalling. 5(3):395-407
- Caron, S.J., Prober, D., Choy, M., and Schier, A.F. (2008) In vivo birthdating by BAPTISM reveals that trigeminal sensory neuron diversity depends on early neurogenesis. Development (Cambridge, England). 135(19):3259-3269
- Low, S.E., Kuwada, J.Y., and Hume, R.I. (2008) Amino acid variations resulting in functional and nonfunctional zebrafish P2X(1) and P2X (5.1) receptors. Purinergic signalling. 4(4):383-392
- Appelbaum, L., Skariah, G., Mourrain, P., and Mignot, E. (2007) Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish. Brain research. 1174(1):66-75
- Kucenas, S., Soto, F., Cox, J.A., and Voigt, M.M. (2006) Selective labeling of central and peripheral sensory neurons in the developing zebrafish using P2X(3) receptor subunit transgenes. Neuroscience. 138(2):641-652
1 - 10 of 15
Show