Gene
axin1
- ID
- ZDB-GENE-000403-1
- Name
- axin 1
- Symbol
- axin1 Nomenclature History
- Previous Names
-
- masterblind
- mbl
- wu:fi22e03
- wu:fj14c08
- wu:fk11b03 (1)
- zgc:109872
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including I-SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in anterior/posterior pattern specification and regulation of signal transduction. Acts upstream of or within several processes, including embryonic morphogenesis; regionalization; and regulation of MAPK cascade. Part of beta-catenin destruction complex. Is expressed in forebrain; habenula; head; midbrain; and vertebral column. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and urinary bladder cancer. Orthologous to human AXIN1 (axin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028927Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20109 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tm13 | Allele with one point mutation | Unknown | Missense | ENU | |
| tm213 | Allele with one point mutation | Unknown | Missense | not specified |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
| Craniometadiaphyseal osteosclerosis with hip dysplasia | 620558 | ||
| ?Caudal duplication anomaly | 607864 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Axin-1/2, tankyrase-binding domain | Axin beta-catenin binding | Axin-like | DIX domain | DIX domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 1/3 | RGS, subdomain 2 | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AY92 | InterPro | 871 | ||||||||||
| UniProtKB:P57094 | InterPro | 835 | ||||||||||
| UniProtKB:A0AB32TFN7 | InterPro | 835 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:GFP-axin1) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-54I21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-25B15 | ZFIN Curated Data | |
| Contains | SNP | rs3727728 | ZFIN Curated Data | |
| Contains | SNP | rs3727729 | ZFIN Curated Data | |
| Encodes | EST | fi22e03 | ZFIN Curated Data | |
| Encodes | EST | fj14c08 | ZFIN Curated Data | |
| Encodes | EST | fk11b03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109872 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131503 (1) | 4742 nt | ||
| Genomic | GenBank:CU138533 (2) | 115648 nt | ||
| Polypeptide | UniProtKB:A0A8M3AY92 (1) | 871 aa |
- Dicipulo, R., Selland, L.G., Carpenter, R.G., Waskiewicz, A.J. (2025) Functional role for Taz during hindbrain ventricle morphogenesis. PLoS One. 20:e0313262e0313262
- Camacho-Macorra, C., Tabanera, N., Sánchez-Bustamante, E., Bovolenta, P., Cardozo, M.J. (2024) Maternal vgll4a regulates zebrafish epiboly through Yap1 activity. Frontiers in cell and developmental biology. 12:13626951362695
- Coppola, U., Saha, B., Kenney, J., Waxman, J.S. (2024) A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish. PLoS Genetics. 20:e1011222e1011222
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Li, B., Chen, K., Liu, F., Zhang, J., Chen, X., Chen, T., Chen, Q., Yao, Y., Hu, W., Wang, L., Wu, Y. (2021) Developmental Angiogenesis Requires the Mitochondrial Phenylalanyl-tRNA Synthetase. Frontiers in cardiovascular medicine. 8:724846
- Sharma, S., Kumar, M., Kumar, J., Srivastava, N., Hussain, M.A., Shelly, A., Mazumder, S. (2021) M. fortuitum-induced CNS-pathology: Deciphering the role of canonical Wnt signaling, blood brain barrier components and cytokines. Developmental and comparative immunology. 122:104111
- Costa, R., Bellesso, S., Lualdi, S., Manzoli, R., Pistorio, V., Filocamo, M., Moro, E. (2020) A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models. Human molecular genetics. 29:285
- Gao, X., Huang, S.S., Qiu, S.W., Su, Y., Wang, W.Q., Xu, H.Y., Xu, J.C., Kang, D.Y., Dai, P., Yuan, Y.Y. (2020) Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms. Journal of Medical Genetics. 58(7):465-474
- Guglielmi, L., Bühler, A., Moro, E., Argenton, F., Poggi, L., Carl, M. (2020) Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry. Development (Cambridge, England). 147(6):
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