Gene
notch2
- ID
- ZDB-GENE-000329-4
- Name
- notch receptor 2
- Symbol
- notch2 Nomenclature History
- Previous Names
-
- notch6
- sb:cb884
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity. Acts upstream of or within several processes, including face morphogenesis; lymphangiogenesis; and pancreas regeneration. Predicted to be located in nucleus and plasma membrane. Predicted to be part of receptor complex. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin; and splanchnocranium. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 42 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb884 (11 images)
- eu314 (4 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| el515 | Allele with one delins | Unknown | Premature Stop | TALEN | |
| el517 | Allele with one deletion | Exon 4 | Frameshift, Premature Stop | TALEN | |
| la016287Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7129 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25391 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31643 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34370 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34371 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38684 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41176 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-notch2 | Varshney et al., 2015 | |
| CRISPR2-notch2 | Varshney et al., 2015 | |
| CRISPR3-notch2 | (2) | |
| CRISPR4-notch2 | (2) | |
| CRISPR5-notch2 | (2) | |
| CRISPR6-notch2 | (2) | |
| CRISPR7-notch2 | (2) | |
| CRISPR8-notch2 | (2) | |
| CRISPR9-notch2 | (2) | |
| CRISPR10-notch2 | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alagille syndrome | Alliance | Alagille syndrome 2 | 610205 |
| Hajdu-Cheney syndrome | Alliance | Hajdu-Cheney syndrome | 102500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Neurogenic locus notch homolog protein 2 | Notch | NOTCH1 EGF-like calcium-binding domain | Notch and Slit guidance protein | Notch, C-terminal | Notch domain | Notch-like domain superfamily | Notch, NOD domain | Notch, NODP domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RCH4 | InterPro | 2475 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
notch2-201
(1)
|
Ensembl | 10,095 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(notch2:notch2-GAL4FF) |
|
|
| 1 | Ando et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-281K2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-183C17 | ZFIN Curated Data | |
| Contains | STS | chunp30626 | ||
| Contains | STS | unp109 | ||
| Encodes | EST | cb884 | ||
| Encodes | EST | eu314 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001115094 (1) | 10095 nt | ||
| Genomic | GenBank:CT573380 (1) | 124662 nt | ||
| Polypeptide | UniProtKB:F1RCH4 (1) | 2475 aa |
- Duan, W., Huang, G., Sui, Y., Wang, K., Yu, Y., Chu, X., Cao, X., Chen, L., Liu, J., Eichler, E.E., Xiong, B. (2024) Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 121:e2404173121e2404173121
- Cotellessa, L., Marelli, F., Duminuco, P., Adamo, M., Papadakis, G.E., Bartoloni, L., Sato, N., Lang-Muritano, M., Troendle, A., Dhillo, W.S., Morelli, A., Guarnieri, G., Pitteloud, N., Persani, L., Bonomi, M., Giacobini, P., Vezzoli, V. (2023) Defective Jagged1 signaling impacts GnRH development and contributes to congenital hypogonadotropic hypogonadism. JCI insight. 8(5):
- Song, K., Lin, Z., Cao, L., Lu, B., Chen, Y., Zhang, S., Lu, J., Xu, H. (2023) Sox11b regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish. Neural regeneration research. 18:445-450
- Xiao, C., Hou, J., Wang, F., Song, Y., Zheng, J., Luo, L., Wang, J., Ding, W., Zhu, X., Xiong, J.W. (2023) Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration. NPJ Regenerative medicine. 8:2121
- Kraus, J.M., Giovannone, D., Rydzik, R., Balsbaugh, J.L., Moss, I.L., Schwedler, J.L., Bertrand, J.Y., Traver, D., Hankenson, K.D., Crump, J.G., Youngstrom, D.W. (2022) Notch signaling enhances bone regeneration in the zebrafish mandible. Development (Cambridge, England). 149(5)
- Li, Y., Tang, C., Liu, F., Zhu, C., Liu, F., Zhu, P., Wang, L. (2022) DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling. Development (Cambridge, England). 149(10):
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Paudel, S., Gjorcheska, S., Bump, P., Barske, L. (2022) Patterning of cartilaginous condensations in the developing facial skeleton. Developmental Biology. 486:44-55
- Sun, J., Chen, Q., Ma, J. (2022) Notch-Sox9 Axis Mediates Hepatocyte Dedifferentiation in KrasG12V-Induced Zebrafish Hepatocellular Carcinoma. International Journal of Molecular Sciences. 23(9):
- Lu, S., Lyu, Z., Wang, Z., Kou, Y., Liu, C., Li, S., Hu, M., Zhu, H., Wang, W., Zhang, C., Kuan, Y.S., Liu, Y.W., Chen, J., Tian, J. (2021) Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 11:2788-2805
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