Gene
or42c4
- ID
- ZDB-GENE-000329-15
- Name
- odorant receptor, family 42, subfamily C, member 4
- Symbol
- or42c4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in olfactory epithelium and olfactory rosette. Orthologous to several human genes including OR1E1 (olfactory receptor family 1 subfamily E member 1); OR1E2 (olfactory receptor family 1 subfamily E member 2); and OR1E3 (olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2789 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32048 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35924 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39059 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Olfactory receptor | Olfactory receptor 51/52/56-like |
|---|---|---|---|---|---|---|
| UniProtKB:Q9PSU4 | InterPro | 325 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
or111-7-201
(1)
|
Ensembl | 1,439 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(or42c4-IRES:GAL4-VP16,myl7:EGFP) |
| 1 | (2) | ||
| TgBAC(or111-7:GAP-YFP,or103-1:GAP-CFP) |
|
| 1 | (3) | |
| Tg(or111-7:or111-7-IRES-GAL4) |
|
|
| 1 | (8) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-133D24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193548 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193566 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131582 (1) | 1439 nt | ||
| Genomic | GenBank:AL845428 (1) | 157787 nt | ||
| Polypeptide | UniProtKB:Q9PSU4 (1) | 325 aa |
No data available
- Dang, P., Barnes, D.T., Cheng, R.P., Xu, A., Ji Moon, Y., Sripad Kodukula, S., Raper, J.A. (2022) Netrins and netrin receptors are essential for normal targeting of sensory axons in the zebrafish olfactory bulb. Neuroscience. 508:19-29
- Olender, T., Jones, T.E.M., Bruford, E., Lancet, D. (2020) A unified nomenclature for vertebrate olfactory receptors. BMC Evolutionary Biology. 20:42
- Dang, P., Fisher, S.A., Stefanik, D., Kim, J., Raper, J.A. (2018) Coordination of olfactory receptor choice with guidance receptor expression and function in olfactory sensory neurons. PLoS Genetics. 14:e1007164
- Shao, X., Lakhina, V., Dang, P., Cheng, R.P., Marcaccio, C.L., Raper, J.A. (2017) Olfactory sensory axons target specific protoglomeruli in the olfactory bulb of zebrafish. Neural Development. 12:18
- Taku, A.A., Marcaccio, C.L., Ye, W., Krause, G.J., Raper, J.A. (2016) Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target. Development (Cambridge, England). 143:123-32
- Saraiva, L.R., Ahuja, G., Ivandic, I., Syed, A.S., Marioni, J.C., Korsching, S.I., Logan, D.W. (2015) Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Scientific Reports. 5:11487
- Lakhina, V., Marcaccio, C.L., Shao, X., Lush, M.E., Jain, R.A., Fujimoto, E., Bonkowsky, J.L., Granato, M., and Raper, J.A. (2012) Netrin/DCC Signaling Guides Olfactory Sensory Axons to Their Correct Location in the Olfactory Bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(13):4440-4456
- Lerebours, A., Bourdineaud, J.P., Ven, K.V., Vandenbrouck, T., Gonzalez, P., Camilleri, V., Floriani, M., Garnier-Laplace, J., and Adam-Guillermin, C. (2010) Sublethal Effects of Waterborne Uranium Exposures on the Zebrafish Brain: Transcriptional Responses and Alterations of the Olfactory Bulb Ultrastructure. Environmental science & technology. 44(4):1438-1443
- Ng, Y.K., Wu, W., and Zhang, L. (2009) Positive correlation between gene coexpression and positional clustering in the zebrafish genome. BMC Genomics. 10:42
- Niimura, Y. (2009) On the Origin and Evolution of Vertebrate Olfactory Receptor Genes: Comparative Genome Analysis Among 23 Chordate Species. Genome biology and evolution. 1:34-44
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