Gene
hoxc9a
- ID
- ZDB-GENE-000328-5
- Name
- homeobox C9a
- Symbol
- hoxc9a Nomenclature History
- Previous Names
-
- BZ-39
- bz39
- hoxc9
- zgc:109844
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of vasculogenesis and positive regulation of lymphangiogenesis. Predicted to be active in nucleus. Is expressed in several structures, including CNS interneuron; axial vasculature; neural tube; pectoral fin bud; and spinal cord. Orthologous to human HOXC9 (homeobox C9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109844 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Stoll et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010794Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hoxc9a | N/A | (2) |
| MO2-hoxc9a | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Abd-B homeobox transcription factor | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein HXA9/HXB9/HXC9 | Homeodomain | Homeodomain, metazoa | Hox9, N-terminal activation domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9YGS6 | InterPro | 260 | |||||||
| UniProtKB:A2BE65 | InterPro | 270 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxc9a-201
(1)
|
Ensembl | 1,170 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-81P22 | ||
| Encodes | EST | wz13644 | ||
| Encodes | cDNA | MGC:109844 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191221 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131528 (1) | 1405 nt | ||
| Genomic | GenBank:BX005254 (1) | 160012 nt | ||
| Polypeptide | UniProtKB:A2BE65 (1) | 270 aa |
- Adachi, U., Koita, R., Seto, A., Maeno, A., Ishizu, A., Oikawa, S., Tani, T., Ishizaka, M., Yamada, K., Satoh, K., Nakazawa, H., Furudate, H., Kawakami, K., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins. Proceedings of the National Academy of Sciences of the United States of America. 121:e2403809121e2403809121
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Hayward, A.G., Joshi, P., Skromne, I. (2015) Spatiotemporal analysis of zebrafish hox gene regulation by Cdx4. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(12):1564-73
- Muto, A., Ikeda, S., Lopez-Burks, M.E., Kikuchi, Y., Calof, A.L., Lander, A.D., Schilling, T.F. (2014) Nipbl and Mediator Cooperatively Regulate Gene Expression to Control Limb Development. PLoS Genetics. 10:e1004671
- Amali, A.A., Sie, L., Winkler, C., and Featherstone, M. (2013) Zebrafish hoxd4a Acts Upstream of meis1.1 to Direct Vasculogenesis, Angiogenesis and Hematopoiesis. PLoS One. 8(3):e58857
- Mehta, T.K., Ravi, V., Yamasaki, S., Lee, A.P., Lian, M.M., Tay, B.H., Tohari, S., Yanai, S., Tay, A., Brenner, S., and Venkatesh, B. (2013) Evidence for at least six Hox clusters in the Japanese lamprey (Lethenteron japonicum). Proceedings of the National Academy of Sciences of the United States of America. 110(40):16044-16049
- Stoll, S.J., Bartsch, S., and Kroll, J. (2013) HOXC9 Regulates Formation of Parachordal Lymphangioplasts and the Thoracic Duct in Zebrafish via Stabilin 2. PLoS One. 8(3):e58311
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