Gene
fzd8b
- ID
- ZDB-GENE-000328-4
- Name
- frizzled class receptor 8b
- Symbol
- fzd8b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within dorsal/ventral pattern formation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including forebrain; hypoblast; mesoderm; neural keel; and presumptive brain. Orthologous to human FZD8 (frizzled class receptor 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76856 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled 8, cysteine-rich domain | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, 7TM | GPCR, family 2-like, 7TM |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PWK6 | InterPro | 576 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-77G15 | ZFIN Curated Data | |
| Encodes | EST | tdsubc_1e1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76856 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131553 (1) | 2522 nt | ||
| Genomic | GenBank:AL954820 (1) | 188661 nt | ||
| Polypeptide | UniProtKB:Q9PWK6 (1) | 576 aa |
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Westphal, M., Panza, P., Kastenhuber, E., Wehrle, J., Driever, W. (2022) Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific Reports. 12:1030
- Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730
- Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):
- Hung, K.S., Hsiao, C.C., Pai, T.W., Hu, C.H., Tzou, W.S., Wang, W.D., Chen, Y.R. (2018) Functional enrichment analysis based on long noncoding RNA associations. BMC systems biology. 12:45
- Coppola, U., Annona, G., D'Aniello, S., Ristoratore, F. (2016) Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evolutionary Biology. 16:26
- Fodor, E., Zsigmond, A., Horváth, B., Molnár, J., Nagy, I., Tóth, G., Wilson, S.W., and Varga, M. (2013) Full transcriptome analysis of early dorsoventral patterning in zebrafish. PLoS One. 8(7):e70053
- Crow, K.D., Smith, C.D., Cheng, J.F., Wagner, G.P., and Amemiya, C.T. (2012) An Independent Genome Duplication Inferred from Hox Paralogs in the American Paddlefish—A Representative Basal Ray-Finned Fish and Important Comparative Reference. Genome biology and evolution. 4(9):937-953
- Hensley, M.R., Emran, F., Bonilla, S., Zhang, L., Zhong, W., Grosu, P., Dowling, J.E., and Leung, Y.F. (2011) Cellular Expression of Smarca4 (Brg1)-regulated Genes in Zebrafish Retinas. BMC Developmental Biology. 11(1):45
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