Gene
tnnt3a
- ID
- ZDB-GENE-000322-3
- Name
- troponin T type 3a (skeletal, fast)
- Symbol
- tnnt3a Nomenclature History
- Previous Names
-
- tnnt
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable tropomyosin binding activity; troponin C binding activity; and troponin I binding activity. Acts upstream of or within sarcomere organization. Predicted to be part of troponin complex. Is expressed in musculature system and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64197 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ferrante et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24709 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ws01961aTg | Transgenic insertion | Exon 6 | Unknown | not specified |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 2B2 | Alliance | Arthrogryposis, distal, type 2B2 | 618435 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Troponin | Troponin domain superfamily | Troponin T |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BAI0 | InterPro | 282 | |||
| UniProtKB:Q9I8U9 | InterPro | 230 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnnt3a-201
(1)
|
Ensembl | 1,138 nt | ||
| ncRNA |
tnnt3a-002
(1)
|
Ensembl | 370 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-201M7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64197 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131565 (1) | 1098 nt | ||
| Genomic | GenBank:BX004812 (1) | 189554 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAI0 (1) | 282 aa |
- Peng, X., Feng, G., Zhang, Y., Sun, Y. (2021) PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction. International Journal of Molecular Sciences. 22(21):
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
- Kwon, O.K., Kim, S.J., Lee, S. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports. 8:3652
- Gomes, R.S., Skroblin, P., Munster, A.B., Tomlins, H., Langley, S.R., Zampetaki, A., Yin, X., Wardle, F., Mayr, M. (2016) "Young at heart": Regenerative potential linked to immature cardiac phenotypes. Journal of Molecular and Cellular Cardiology. 92:105-8
- Quach, H.N., Tao, S., Vrljicak, P., Joshi, A., Ruan, H., Sukumaran, R., Varshney, G.K., LaFave, M.C., Screen Team, T.D., Burgess, S.M., Winkler, C., Emelyanov, A., Parinov, S., Sampath, K. (2015) A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. G3 (Bethesda). 5(6):1283-99
- Todd, P.K., Ackall, F.Y., Hur, J., Sharma, K., Paulson, H.L., and Dowling, J.J. (2014) Transcriptional changes and developmental abnormalities in a Zebrafish model of Myotonic Dystrophy Type 1. Disease models & mechanisms. 7(1):143-55
- Veldman, M.B., Zhao, C., Gomez, G.A., Lindgren, A.G., Huang, H., Yang, H., Yao, S., Martin, B.L., Kimelman, D., and Lin, S. (2013) Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor etv2. PLoS Biology. 11(6):e1001590
- Burguière, A.C., Nord, H., and von Hofsten, J. (2011) Alkali-like myosin light chain-1 (myl1) is an early marker for differentiating fast muscle cells in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(7):1856-1863
- Ferrante, M.I., Kiff, R.M., Goulding, D.A., and Stemple, D.L. (2011) Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle. Journal of Cell Science. 124(Pt 4):565-577
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