Gene
bmp7a
- ID
- ZDB-GENE-000208-25
- Name
- bone morphogenetic protein 7a
- Symbol
- bmp7a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables identical protein binding activity and protein heterodimerization activity. Acts upstream of or within several processes, including BMP signaling pathway; determination of bilateral symmetry; and negative regulation of endodermal cell fate specification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including forebrain; gastrula cell; margin; prechordal plate; and tail bud. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ihb895 | Allele with one deletion | Unknown | Unknown | CRISPR | |
la012084Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa1343 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa15764 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sb1aub | Allele with one point mutation | Unknown | Unknown | spontaneous | |
ty68a | Allele with one point mutation | Unknown | Unknown | ENU | |
zf3598 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 7 of 7
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-bmp7a | Capon et al., 2017 | |
CRISPR2-bmp7a | Hoshijima et al., 2019 | |
CRISPR3-bmp7a | Hoshijima et al., 2019 | |
CRISPR4-bmp7a | Dong et al., 2022 | |
CRISPR5-bmp7a | Wang et al., 2023 | |
MO1-bmp7a | N/A | (7) |
MO2-bmp7a | N/A | (6) |
1 - 7 of 7
Show
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
Domain | IPR001111 | TGF-beta, propeptide |
Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
Family | IPR015615 | Transforming growth factor-beta-related |
Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
1 - 5 of 5
Domain Details Per Protein
Protein | Additional Resources | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
---|---|---|---|---|---|---|---|
UniProtKB:Q9PTF9 | InterPro | 432 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-253B8 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-430F17 | ZFIN Curated Data | |
Encodes | EST | fb83f09 | ZFIN Curated Data |
1 - 3 of 3
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131321 (1) | 3374 nt | ||
Genomic | GenBank:CR925817 (1) | 156864 nt | ||
Polypeptide | UniProtKB:Q9PTF9 (1) | 432 aa |
- Bongiovanni, C., Bueno-Levy, H., Posadas Pena, D., Del Bono, I., Miano, C., Boriati, S., Da Pra, S., Sacchi, F., Redaelli, S., Bergen, M., Romaniello, D., Pontis, F., Tassinari, R., Kellerer, L., Petraroia, I., Mazzeschi, M., Lauriola, M., Ventura, C., Heermann, S., Weidinger, G., Tzahor, E., D'Uva, G. (2024) BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice. Cell Reports. 43:114162114162
- Allen, R.S., Jones, W.D., Hale, M., Warder, B.N., Shore, E.M., Mullins, M.C. (2023) Reduced GS domain serine/threonine requirements of Fibrodysplasia Ossificans Progressiva mutant type I BMP receptor ACVR1 in the zebrafish. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 38(9):1364-1385
- Lau, E.S., Zhu, B., Sun, M.A., Ngai, S.M., Ge, W. (2023) Proteomic analysis of zebrafish Folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian Folliculogenesis. Biology of reproduction. 109(4):482-497
- Mignani, L., Facchinello, N., Varinelli, M., Massardi, E., Tiso, N., Ravelli, C., Mitola, S., Schu, P., Monti, E., Finazzi, D., Borsani, G., Zizioli, D. (2023) Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies. International Journal of Molecular Sciences. 24(8):
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Gao, M., Veil, M., Rosenblatt, M., Riesle, A.J., Gebhard, A., Hass, H., Buryanova, L., Yampolsky, L.Y., Grüning, B., Ulianov, S.V., Timmer, J., Onichtchouk, D. (2022) Pluripotency factors determine gene expression repertoire at zygotic genome activation. Nature communications. 13:788
- Mostofa, F., Yasid, N.A., Shamsi, S., Ahmad, S.A., Mohd-Yusoff, N.F., Abas, F., Ahmad, S. (2022) In Silico Study and Effects of BDMC33 on TNBS-Induced BMP Gene Expressions in Zebrafish Gut Inflammation-Associated Arthritis. Molecules. 27(23):
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Castro, J., Beviano, V., Paço, A., Leitão-Castro, J., Cadete, F., Francisco, M., Freitas, R. (2021) Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design. Scientific Reports. 11:7165
1 - 10 of 128
Show