Gene

bmp7a

ID
ZDB-GENE-000208-25
Name
bone morphogenetic protein 7a
Symbol
bmp7a Nomenclature History
Previous Names
  • bmp7 (1)
  • fb83f09
  • snailhouse
  • snh
  • wu:fb83f09 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Enables identical protein binding activity and protein heterodimerization activity. Acts upstream of or within several processes, including BMP signaling pathway; determination of bilateral symmetry; and negative regulation of endodermal cell fate specification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including forebrain; gastrula cell; margin; prechordal plate; and tail bud. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
27 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
24 figures from 16 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb895Allele with one deletionUnknownUnknownCRISPR
la012084TgTransgenic insertionUnknownUnknownDNA
sa1343Allele with one point mutationUnknownPremature StopENU
sa15764Allele with one point mutationUnknownPremature StopENU
sb1aubAllele with one point mutationUnknownUnknownspontaneous
ty68aAllele with one point mutationUnknownUnknownENU
zf3598Allele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With bmp7a Human Ortholog
No data available
Associated With bmp7a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
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Domain Details Per Protein
Protein Additional Resources Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:Q9PTF9 InterPro 432
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA bmp7a-201 (1) Ensembl 3,384 nt
mRNA bmp7a-202 (1) Ensembl 973 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-253B8ZFIN Curated Data
Contained inFosmidCH1073-430F17ZFIN Curated Data
EncodesESTfb83f09ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanBMP720
Amino acid sequence comparison (3)
MouseBmp72
Amino acid sequence comparison (2)
Citations
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