Gene
dbx2
- ID
- ZDB-GENE-000128-13
- Name
- developing brain homeobox 2
- Symbol
- dbx2 Nomenclature History
- Previous Names
-
- H2.0-like homeobox 3
- hlx3
- zgc:110519
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within swimming behavior. Predicted to be located in nucleus. Is expressed in eye; spinal cord; spinal cord neural tube; and tegmentum. Orthologous to human DBX2 (developing brain homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | H2.0 Homeobox Neural Patterning | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PP76 | InterPro | 199 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Juárez-Morales, J.L., Weierud, F., England, S.J., Demby, C., Santos, N., Grieb, G., Mazan, S., Lewis, K.E. (2021) Evolution of lbx spinal cord expression and function. Evolution & development. 23(5):404-422
- Seese, S.E., Deml, B., Muheisen, S., Sorokina, E., Semina, E.V. (2021) Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(8):1056-1073
- Ma, P., Song, N.N., Cheng, X., Zhu, L., Zhang, Q., Zhang, L., Yang, X., Wang, H., Kong, Q., Shi, D., Ding, Y.Q., Mao, B. (2019) ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling. Journal of molecular cell biology. 12(5):337-344
- Kim, J., Choi, T.I., Park, S., Kim, M.H., Kim, C.H., Lee, S. (2018) Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains.. Development (Cambridge, England). 145(17):
- May, M., Hwang, K.S., Miles, J., Williams, C., Niranjan, T., Kahler, S.G., Chiurazzi, P., Steindl, K., van der Spek, P.J., Swagemakers, S., Mueller, J., Stefl, S., Alexov, E., Ryu, J.I., Choi, J.H., Kim, H.T., Tarpey, P., Neri, G., Holloway, L., Skinner, C., Stevenson, R.E., Dorsky, R.I., Wang, T., Schwartz, C.E., Kim, C.H. (2015) ZC4H2, an XLID Gene, is Required for the Generation of a Specific Subset of CNS Interneurons. Human molecular genetics. 24(17):4848-61
- Hui, S.P., Sengupta, D., Lee, S.G., Sen, T., Kundu, S., Mathavan, S., and Ghosh, S. (2014) Genome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish. PLoS One. 9(1):e84212
- Zannino, D.A., Downes, G.B., Sagerström, C.G. (2014) prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements. Developmental Biology. 390:247-60
- Satou, C., Kimura, Y., Hirata, H., Suster, M.L., Kawakami, K., and Higashijima, S. (2013) Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development (Cambridge, England). 140(18):3927-3931
- England, S., Batista, M.F., Mich, J.K., Chen, J.K., and Lewis, K.E. (2011) Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons. Development (Cambridge, England). 138(23):5121-5134
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