Gene
dbx1b
- ID
- ZDB-GENE-000128-11
- Name
- developing brain homeobox 1b
- Symbol
- dbx1b Nomenclature History
- Previous Names
-
- H2.0-like homeobox 2
- hlx2
- sb:eu236
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Acts upstream of or within cell differentiation in spinal cord. Predicted to be located in nucleus. Is expressed in several structures, including brain; hindbrain neural plate; neural tube; presumptive diencephalon; and spinal cord neural rod. Orthologous to human DBX1 (developing brain homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu236 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dbx1b | Jurgens et al., 2025 | |
| CRISPR2-dbx1b | Jurgens et al., 2025 | |
| CRISPR3-dbx1b | Jurgens et al., 2025 | |
| CRISPR4-dbx1b | Jurgens et al., 2025 | |
| MO1-dbx1b | N/A | Gribble et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | H2.0 Homeobox Neural Patterning | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DG51 | InterPro | 322 | ||||||
| UniProtKB:Q9PTU0 | InterPro | 322 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(dbx1b:Cre-mCherry) |
|
| 1 | (16) | |
| TgBAC(dbx1b:GFP) |
|
| 1 | (10) | |
| TgBAC(dbx1b:LOXP-DsRed-LOXP-EGFP) |
|
| 1 | (3) | |
| TgBAC(dbx1b:Tomato-NLS) |
|
| 1 | Roberson et al., 2017 | |
| Tg(dbx1b:EGFP) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-101M21 | ZFIN Curated Data | |
| Encodes | EST | eu236 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193869 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193890 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131178 (1) | 1429 nt | ||
| Genomic | GenBank:CR383674 (1) | 212086 nt | ||
| Polypeptide | UniProtKB:B3DG51 (1) | 322 aa |
- Jurgens, J.A., Matos Ruiz, P.M., King, J., Foster, E.E., Berube, L., Chan, W.M., Barry, B.J., Jeong, R., Rothman, E., Whitman, M.C., MacKinnon, S., Rivera-Quiles, C., Pratt, B.M., Easterbrooks, T., Mensching, F.M., Di Gioia, S.A., Pais, L., England, E.M., de Berardinis, T., Magli, A., Koc, F., Asakawa, K., Kawakami, K., O'Donnell-Luria, A., Hunter, D.G., Robson, C.D., Bulyk, M.L., Engle, E.C. (2025) Gene Identification for Ocular Congenital Cranial Motor Neuron Disorders Using Human Sequencing, Zebrafish Screening, and Protein Binding Microarrays. Investigative ophthalmology & visual science. 66:6262
- Matsumoto, K., Akieda, Y., Haraoka, Y., Hirono, N., Sasaki, H., Ishitani, T. (2024) Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nature communications. 15:1066210662
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Tsai, T.Y., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.P., Megason, S.G. (2020) An adhesion code ensures robust pattern formation during tissue morphogenesis. Science (New York, N.Y.). 370:113-116
- Gerber, V., Yang, L., Takamiya, M., Ribes, V., Gourain, V., Peravali, R., Stegmaier, J., Mikut, R., Reischl, M., Ferg, M., Rastegar, S., Strähle, U. (2019) The HMG box transcription factors Sox1a and b specify a new class of glycinergic interneurons in the spinal cord of zebrafish embryos. Development (Cambridge, England). 146(4):
- Roberson, S., Halpern, M.E. (2017) Convergence of signaling pathways underlying habenular formation and axonal outgrowth. Development (Cambridge, England). 144(14):2652-2662
- Gebauer, J.M., Kobbe, B., Paulsson, M., Wagener, R. (2016) Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 49:106-19
- Juárez-Morales, J.L., Schulte, C.J., Pezoa, S.A., Vallejo, G.K., Hilinski, W.C., England, S.J., de Jager, S., Lewis, K.E. (2016) Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Development. 11:5
- Kuan, Y.S., Roberson, S., Akitake, C.M., Fortuno, L., Gamse, J., Moens, C., Halpern, M.E. (2015) Distinct requirements for Wntless in habenular development. Developmental Biology. 406(2):117-28
- Lee, M.M., Arrenberg, A.B., Aksay, E.R. (2015) A structural and genotypic scaffold underlying temporal integration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:7903-20
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