FISH

adgrg6^{tb233c/tb233c}

ID: ZDB-FISH-150901-443
Name: adgrg6^{tb233c/tb233c}
Genotype: adgrg6^{tb233c/tb233c}
Targeting Reagent

Human Disease modelled by adgrg6^{tb233c/tb233c}

No data available

Gene Expression

RNA Expression

Protein Expression

Antibody	Antigen Gene	Structure	Conditions	Figures
Ab1-col2a		inner ear semicircular canal otic vesicle protrusion	standard conditions	Fig. 4 from Geng et al., 2013

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Reporter Gene Expression

No data available

Phenotype

Phenotype	Conditions	Figures
inner ear increased size, abnormal	standard conditions	Fig. 3 from Whitfield et al., 1996
inner ear swollen, abnormal	standard conditions	Fig. 2 Fig. 8 from Geng et al., 2013
otic vesicle protrusion disorganized, abnormal	standard conditions	Fig. 4 from Geng et al., 2013
peripheral nervous system mbpa expression decreased distribution, abnormal	chemical treatment: FPL 64176	Figure 6. from Diamantopoulou et al., 2019
peripheral nervous system mbpa expression decreased distribution, abnormal	standard conditions	Fig. 1 Figure 6. from Diamantopoulou et al., 2019
pillar of the anterior semicircular canal vcanb expression increased amount, abnormal	chemical treatment: nifedipine	Figure 6. from Diamantopoulou et al., 2019
pillar of the anterior semicircular canal vcanb expression increased amount, abnormal	chemical treatment: cilnidipine	Figure 6. from Diamantopoulou et al., 2019
pillar of the anterior semicircular canal vcanb expression increased amount, abnormal	standard conditions	Fig. 1 Figure 6. Figure 8. from Diamantopoulou et al., 2019
pillar of the anterior semicircular canal swollen, abnormal	standard conditions	Fig. 1 Fig. 7 from Diamantopoulou et al., 2019
pillar of the anterior semicircular canal swollen, ameliorated	chemical treatment: nifedipine	Fig. 7 from Diamantopoulou et al., 2019

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Citations

Include unpublished citations

Diamantopoulou, E., Baxendale, S., de la Vega de León, A., Asad, A., Holdsworth, C.J., Abbas, L., Gillet, V.J., Wiggin, G.R., Whitfield, T.T. (2019) Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. eLIFE. 8:
Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374
Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254

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