FIGURE

Fig. 5

ID

ZDB-FIG-241119-111

Publication

Kapp et al., 2024 - Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Response to targeted therapy in P1. a Patient P1 at 5 months of age. b Patient P1 at 6 months of age (after a bleeding episode). c Patient P1 at 28 months of age, showing a significant and progressive enlargement of the right cheek due to the AVM. d MRI (transversal T2 STIR) of the Patient P1 before the start of trametinib treatment; red dashed line indicates the extent of the AVM. e MRI (transversal T2 TSE Dixon) of the Patient P1 after 5 months of treatment with trametinib; red dashed line indicates the now smaller extent of the AVM. f Patient P1 at 38 months of age, reduced volume of the right cheek and fading of the capillary malformation can be noted

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Angiogenesis