FIGURE

Fig. 5

ID

ZDB-FIG-240308-8

Publication

Koparir et al., 2024 - Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome

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Fig. 5

A In situ hybridization images of tbx6 (tbx6r/fss/fussed somites/tbx24) and tbx16 (spt/spatetail) expression in injected embryos 19 hpf showing mosaic transient-transgenic overexpression of wild-type msgn1. Expression of tbx6 and tbx16 was detected in PSM cells (endogenous expression) and within the trunk, colocalizing with notochord alterations (shown in higher magnification). B In 30 hpf old msgn1 mosaic embryos, ectopic expression of bmp2a was detected in the head region, consistent with strong ectopic msgn1 expression in trunk and head regions of injected embryos at this stage

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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