Engineered Foreign Gene
hM3Dq
- ID
- ZDB-EFG-240927-1
- Name
- modified human M3 muscarinic (hM3) receptor
- Symbol
- hM3Dq
- Previous Names
- None
- Type
- engineered_foreign_gene
- Location
- Unmapped
- Note
-
hM3Dq is a modified form of the human M3 muscarinic (hM3) receptor. It can be activated by the inert clozapine metabolite clozapine-N-oxide (CNO), engaging the Gq signaling pathway. Gq signaling releases intracellular calcium stores and enhances neuronal excitation. Thus, neurons expressing hM3Dq treated with CNO are observed to have dramatically increased firing rates
Expression
- All Expression Data
- No data available
Constructs
Sequence Information
Citations