Engineered Foreign Gene

hM3Dq

ID
ZDB-EFG-240927-1
Name
modified human M3 muscarinic (hM3) receptor
Symbol
hM3Dq
Previous Names
None
Type
engineered_foreign_gene
Location
Unmapped
Note
hM3Dq is a modified form of the human M3 muscarinic (hM3) receptor. It can be activated by the inert clozapine metabolite clozapine-N-oxide (CNO), engaging the Gq signaling pathway. Gq signaling releases intracellular calcium stores and enhances neuronal excitation. Thus, neurons expressing hM3Dq treated with CNO are observed to have dramatically increased firing rates
Expression
All Expression Data
No data available
Constructs
Antibodies
No data available
Sequence Information
Citations
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