Antibody

Ab1-cacna1s

Antibody ID

ZDB-ATB-140514-1

Antibody Name

Ab1-cacna1s

Previous Names

ab2862 (1)
anti-DHPR (1)
clone 1A (1)
MA3-920 (1)
anti-CACNA1S calcium channel, voltage-dependent, L type, alpha 1S (1)
anti-dihydropyridine receptor (1)

Host Organism

Mouse

Immunogen Organism

Rabbit

Isotype

IgG1

Type

monoclonal

Assays

Antigen Genes

Antibody Registry ID

AB_2069575

Source

Abcam plc
Affinity BioReagents (Thermo Fisher Scientific)

Notes

Comment	Citation
immunogen is purified rabbit muscle T-tubule dihydropyridine receptor.	ZFIN Curated Data

Anatomical Labeling

Antibody Labeling Summary

Citations

Include unpublished citations

Endo, Y., Groom, L., Wang, S.M., Pannia, E., Griffiths, N.W., Van Gennip, J.L.M., Ciruna, B., Laporte, J., Dirksen, R.T., Dowling, J.J. (2023) Two zebrafish cacna1s loss-of-function variants provide models of mild and severe CACNA1S-related myopathy. Human molecular genetics. 33(3):254-269
Dayal, A., Ng, S.F.J., Grabner, M. (2019) Ca²⁺-activated Cl^- channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration. Nature communications. 10:115
Linsley, J.W., Hsu, I.U., Groom, L., Yarotskyy, V., Lavorato, M., Horstick, E.J., Linsley, D., Wang, W., Franzini-Armstrong, C., Dirksen, R.T., Kuwada, J.Y. (2017) Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proceedings of the National Academy of Sciences of the United States of America. 114(2):E228-E236
Linsley, J.W., Hsu, I.U., Wang, W., Kuwada, J.Y. (2017) Transport of the alpha subunit of the L-type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles. Traffic (Copenhagen, Denmark). 18(9):622-632
Xiyuan, Z., Fink, R.H.A., Mosqueira, M. (2017) NO-sGC Pathway Modulates Ca²⁺ Release and Muscle Contraction in Zebrafish Skeletal Muscle.. Frontiers in Physiology. 8:607
Fero, K., Bergeron, S.A., Horstick, E.J., Codore, H., Li, G.H., Ono, F., Dowling, J.J., and Burgess, H.A. (2014) Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure. Disease models & mechanisms. 7(2):289-98

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