Genomic Feature
hi2211Tg
- ID
- ZDB-ALT-040827-6
- Name
- hi2211Tg
- Synonyms
-
- hi2211 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (2)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the plus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 20: 38837792 - 388337793 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ift172hi2211Tg/hi2211Tg | Homozygous | ♀+/- ♂+/- | 13 figures  from 5 publications | 7 figures from 3 publications | |
| ift172hi2211Tg/hi2211Tg (AB) | Homozygous | ♀+/- ♂+/- | Fig. 1 from Kallakuri et al., 2015 | ||
| ift172hi2211Tg/hi2211Tg (AB/TL) | Homozygous | ♀+/- ♂+/- | |||
| ift172hi2211Tg/hi2211Tg (AB/TU) | Homozygous | ♀+/- ♂+/- | 3 figures from 2 publications | ||
| ift172hi2211Tg/+ (AB) | Heterozygous | Unknown | |||
| ift172hi2211Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| ift172hi2211Tg | Unknown | Unknown | Fig. for (hi2211) from Phenotype Annotation (1994-2006) | ||
| ift172hi2211Tg/hi2211Tg; sd2Tg; y1Tg | Complex | Fig. 5 from Eisa-Beygi et al., 2018 | |||
| ift172pd1085/+; ift172hi2211Tg/+ | Complex | Fig. 2 from Ryan et al., 2013 | |||
| dnaaf11hi3308Tg/hi3308Tg; ift172hi2211Tg/hi2211Tg (AB/TU) | Complex | 2 figures from Kishimoto et al., 2008 |
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Supplemental Information
- Genotyping protocol
- hi2211tg.pdf
- Pollock, L.M., Perkins, B., Anand-Apte, B. (2020) Primary cilia are present on endothelial cells of the hyaloid vasculature but are not required for the development of the blood-retinal barrier. PLoS One. 15:e0225351
- Eisa-Beygi, S., Benslimane, F.M., El-Rass, S., Prabhudesai, S., Abdelrasoul, M.K.A., Simpson, P.M., Yalcin, H.C., Burrows, P.E., Ramchandran, R. (2018) Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish ( Danio rerio). Arteriosclerosis, Thrombosis, and Vascular Biology. 38:2806-2818
- Xu, W., Jin, M., Hu, R., Wang, H., Zhang, F., Yuan, S., Cao, Y. (2017) The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society of Nephrology : JASN. 28(1):118-129
- Kallakuri, S., Yu, J.A., Li, J., Li, Y., Weinstein, B.M., Nicoli, S., Sun, Z. (2015) Endothelial Cilia Are Essential for Developmental Vascular Integrity in Zebrafish. Journal of the American Society of Nephrology : JASN. 26(4):864-75
- Ryan, S., Willer, J., Marjoram, L., Bagwell, J., Mankiewicz, J., Leshchiner, I., Goessling, W., Bagnat, M., and Katsanis, N. (2013) Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Development (Cambridge, England). 140(21):4445-4451
- Zhao, L., Yuan, S., Cao, Y., Kallakuri, S., Li, Y., Kishimoto, N., Dibella, L., and Sun, Z. (2013) Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proceedings of the National Academy of Sciences of the United States of America. 110(31):12697-702
- Cao, Y., Park, A., and Sun, Z. (2010) Intraflagellar Transport Proteins Are Essential for Cilia Formation and for Planar Cell Polarity. Journal of the American Society of Nephrology : JASN. 21(8):1326-1333
- Cao, Y., Semanchik, N., Lee, S.H., Somlo, S., Barbano, P.E., Coifman, R., and Sun, Z. (2009) Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Proceedings of the National Academy of Sciences of the United States of America. 106(51):21819-21824
- Lunt, S.C., Haynes, T., and Perkins, B.D. (2009) Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(7):1744-1759
- Sukumaran, S., and Perkins, B.D. (2009) Early defects in photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 Intraflagellar Transport mutants. Vision Research. 49(4):479-489
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